PASSIVE MECHANICS AND CONNECTIVE-TISSUE COMPOSITION OF CANINE ARTERIES
PASSIVE MECHANICS AND CONNECTIVE-TISSUE COMPOSITION OF CANINE ARTERIES
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DOI：
10.1152/ajpheart.1978.234.5.h533
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发表时间：
1978-01-01
影响因子：
--
通讯作者：
COX, RH
中科院分区：
文献类型：
--
作者：
COX, RH
犬颈动脉、肾动脉、肠系膜动脉、髂动脉和冠状动脉的完整圆柱段在体外被动平滑肌条件下进行了研究，以将被动力学特性与结缔组织成分相关联。在0-250 mmHg缓慢持续充气条件下测量外径、轴向壁力和跨壁压。这些数据被用来计算值的壁应力和应变分量，增量和各向异性弹性常数，应变能密度。在这些相同的节段上测定胶原蛋白（C）和弹性蛋白（E）含量、水含量、总结缔组织含量（C + E）和C/E。这几个部位的C/E和被动力学性能之间没有明显的关系。低应变增量模量值与弹性蛋白含量相关性良好，但高应变增量模量值与胶原蛋白含量相关性不好。在125毫米汞柱的增量弹性模量值没有相关性以及与胶原蛋白和弹性蛋白含量。使用胶原和弹性蛋白纤维平行排列的简单模型，这些动脉的被动力学性质的差异可以通过在不同压力（或应变）下支持壁应力的胶原纤维的分数和它们的含水量的差异来解释。动脉壁仍然可以被视为均匀结构。
Intact cylindrical segments of canine carotid, renal, mesenteric, iliac and coronary arteries were studied in vitro under conditions of passive smooth muscle to correlate passive mechanical properties with connective tissue composition. Measurements of external diameter, axial wall force and transmural pressure were made under conditions of slow continuous inflation between 0-250 mmHg. These data were used to compute values of wall stress and strain components, incremental and anisotropic elastic constants, and strain energy density. Collagen (C) and elastin (E) content, water content, total connective tissue content (C + E), and C/E were determined on these same segments. No clear relation was found between C/E and passive mechanical properties for these several sites. Values of low-strain incremental modulus correlated well with elastin content, but values of high-strain incremental modulus did not correlate well with collagen content. Values of incremental elastic moduli at 125 mmHg did not correlate well with collagen and elastin content. Using a simple model of collagen and elastin fibers arranged in parallel, differences in the passive mechanical properties of these arteries can be accounted for by differences in the fraction of collagen fibers supporting wall stress at different pressures (or strains) and in their water content. The arterial wall can still be treated as a homogeneous structure.