The 70-kDa Peroxisomal Membrane Protein

The 70-kDa Peroxisomal Membrane Protein
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70 kDa 过氧化物酶体膜蛋白

DOI:
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发表时间:
1992
期刊:
影响因子:
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通讯作者:
T. Osumi
T. Osumi
中科院分区:
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文献类型:
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作者:
T. Hashimoto;T. Kamijo;I. Ueno;K. Kamijo;T. Osumi

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70 kDa过氧化物酶体膜多肽是过氧化物酶体的主要组成多肽之一,其含量随过氧化物酶体增殖而变化雅阁。对该膜多肽cDNA的结构分析和拓扑学研究表明,该膜多肽通过氨基端的6个跨膜片段锚定在膜上,羧基端具有ATP结合结构域的区域暴露于胞浆中。这种蛋白质的可能作用进行了讨论。
The 70 kDa peroxisomal membrane polypeptide is one of the major integral polyeptides and its content varies in accord with proliferation of peroxisomes. The structural analysis of the cDNA for this polypeptide and its topological study indicate that this membrane polypeptide anchors to the membrane via six transmembrane segments on amino-terminus, and the carboxy-terminal region having ATP-binding domain exposes to the cytosol. The possible role of this protein is discussed.