Various approaches to modify biomaterial surfaces for improving hemocompatibility
Various approaches to modify biomaterial surfaces for improving hemocompatibility
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DOI：
10.1016/j.cis.2004.02.001
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发表时间：
2004-06-30
影响因子：
15.6
通讯作者：
Lin, SC
中科院分区：
文献类型：
--
作者：
Mao, C;Qiu, YZ;Lin, SC
本文综述了高分子材料表面血栓形成的机理以及改性生物材料表面以提高其血液相容性的各种方法。此外，还研究了辐射接枝o -丁基壳聚糖（OBCS）纤维素膜的血液相容性。通过衰减全反射傅里叶变换红外光谱（ATR-FTIR）和化学分析电子能谱（ESCA）验证了接枝纤维素膜的表面分析，证实了OBCS成功接枝到纤维素膜表面。以空白纤维素膜为对照，通过富血小板血浆（PRP）接触实验和蛋白质吸附实验评价纤维素膜的血液相容性。移植物纤维素膜的血液相容性优于空白纤维素膜。这些结果表明，所制备的光交联壳聚糖在医学上具有接触血液的应用潜力。(C) 2004 Elsevier B.V.版权所有
In this paper, the mechanism of thrombus formation on the surface of polymeric materials and the various approaches of modifying biomaterial surfaces to improve their hemocompatibility are reviewed. Moreover, the blood compatibility of the cellulose membrane grafted with O-butyrylchitosan (OBCS) by using a radiation grafting technique was studied. Surface analysis of grafted cellulose membrane was verified by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and electron spectroscopy for chemical analysis (ESCA), which confirmed that OBCS was successfully grafted onto the cellulose membrane surfaces. Blood compatibility of the grafted cellulose membranes was evaluated by platelet rich plasma (PRP) contacting experiments and protein adsorption experiments using blank cellulose membranes as the control. The blood compatibility of OBCS grafted cellulose membranes is better than that of blank cellulose membranes. These results suggest that the photocrosslinkable chitosan developed here has the potential of serving in blood-contacting applications in medical use. (C) 2004 Elsevier B.V. All rights reserved.