INDUCTION OF FOOD-INTAKE BY A GABAERGIC MECHANISM IN THE TURKEY
INDUCTION OF FOOD-INTAKE BY A GABAERGIC MECHANISM IN THE TURKEY
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DOI：
10.1016/0031-9384(91)90268-s
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发表时间：
1991-03-01
影响因子：
2.9
通讯作者：
DENBOW, DM
中科院分区：
文献类型：
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作者：
DENBOW, DM
研究了GABA能对大白色火鸡摄食量和饮水量的影响。 在实验1中，监测了脑室内（ICV）注射不同剂量蝇蕈醇（一种GABA激动剂）的母鸡的食物和水摄入量。 在实验2中，在注射蝇蕈醇之前，用ICV注射印防己毒素（一种GABA拮抗剂）对母鸡进行预处理。 在实验3中，在不允许获得食物的母鸡中确定蝇蕈醇的ICV注射对水摄入量的影响。 ICV注射蝇蕈醇导致食物摄入量呈剂量依赖性增加，75纳摩尔是最有效的剂量。 水的摄入量刺激后蝇蕈醇注射时，食物和水可随意。 然而，如果不能同时获得食物，则ICV注射蝇蕈醇不会影响饮水量，这表明饮水量增加是食物摄入量增加的结果。 蝇蕈醇对食物摄入的影响显着减弱与印防己毒素预处理。 因此，似乎GABA在火鸡的大脑中起作用，以增加食物，而不是水的摄入量。
The effect of GABAergic influences on food and water intake in Large White turkeys was investigated. In Experiment 1, food and water intake were monitored in hens injected intracerebroventricularly (ICV) with varying doses of muscimol, a GABA agonist. In Experiment 2, hens were pretreated with ICV injections of picrotoxin, a GABA antagonist, prior to the injection of muscimol. In Experiment 3, the effect of ICV injections of muscimol on water intake was determined in hens not allowed access to food. The ICV injection of muscimol caused a dose-dependent increase in food intake with 75 nmole being the most efficacious dose. Water intake was stimulated following the injection of muscimol when food and water were available ad lib. However, water intake was not affected by the ICV injection of muscimol if food was not simultaneously available, indicating that the increased water intake was a result of increased food intake. The effect of muscimol on food intake was significantly attenuated by pretreatment with picrotoxin. It appears, therefore, that GABA acts within the brain of the turkey to increase food, but not water, intake.