Early Detection of Pressure Ulcer Development Following Traumatic Spinal Cord Injury Using Inflammatory Mediators
Early Detection of Pressure Ulcer Development Following Traumatic Spinal Cord Injury Using Inflammatory Mediators
复制标题
使用炎症介质早期检测外伤性脊髓损伤后压疮的发展
DOI：
10.1016/j.apmr.2016.01.003
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发表时间：
2016-10-01
影响因子：
4.3
通讯作者：
Brienza, David M.
中科院分区：
文献类型：
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作者：
Krishnan, Shilpa;Karg, Patricia E.;Brienza, David M.
目的：探讨创伤性脊髓损伤（SCI）后和首次压疮发生前血浆和尿液中炎症介质浓度的变化。设计:回顾性;对现有数据进行二次分析。地点：一所大学医疗中心的急性住院和住院康复中心。参与者：有压疮和血浆样本的个体（n=17）和有压疮和尿液样本的个体（n=15）按年龄和血浆/尿液样本天数与无压疮的SCI个体（n= 35）匹配。干预措施：不适用。主要观察指标：对脊髓损伤患者的血浆和尿液进行检测，采集脊髓损伤后4天至第一次压疮形成前一周的样本。采用Wilcoxon符号秩检验来确定两个时间点之间炎症介质的变化。结果：血浆趋化因子干扰素- γ诱导蛋白10kd/CXCL10浓度升高(P
Objective: To identify changes in concentrations of inflammatory mediators in plasma and urine after traumatic spinal cord injury (SCI) and before the occurrence of a first pressure ulcer.Design: Retrospective; secondary analysis of existing data.Setting: Acute hospitalization and inpatient rehabilitation sites at a university medical center.Participants: Individuals with a pressure ulcer and plasma samples (n=17) and individuals with a pressure ulcer and urine samples (n=15) were matched by age and plasma/urine sample days to individuals with SCI and no pressure ulcer (N= 35).Interventions: Not applicable.Main Outcome Measures: Plasma and urine samples were assayed in patients with SCI, capturing samples within 4 days after the SCI to a week before the formation of the first pressure ulcer. The Wilcoxon signed-rank test was performed to identify changes in the inflammatory mediators between the 2 time points.Results: An increase in concentration of the chemokine interferon-gamma-induced protein of 10kd/CXCL10 in plasma (P