Site-specific skeletal muscle echo intensity and thickness differences in subcutaneous adipose tissue matched older and younger adults
Site-specific skeletal muscle echo intensity and thickness differences in subcutaneous adipose tissue matched older and younger adults
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DOI：
10.1111/cpf.12679
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发表时间：
2020-11-23
影响因子：
1.8
通讯作者：
Mourtzakis, Marina
中科院分区：
文献类型：
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作者：
Paris, Michael T.;Letofsky, Noah;Mourtzakis, Marina
背景与年龄相关的肌肉质量恶化并不是在全身范围内均匀发生的。然而，对于与年龄相关的全身肌肉成分变化的一致性的了解有限。目的我们的主要目标是评估年轻人和老年人在多个肌肉组之间的肌肉组成差异。方法我们重新分析了先前发表的队列数据，以评估与前臂、前部大腿和腹部肌肉的脂肪组织质量匹配时，年轻人(60岁)之间超声肌肉成分(回声强度)的差异。回声强度的分析与肌肉覆盖的皮下脂肪组织(SAT)厚度相混淆；我们通过将老年人和年轻人(1：1)按性别分层匹配每个地标的绝对SAT厚度来解释这些影响。结果96名成年人(n=女性)中，58(n=34)名成年人上臂前部SAT匹配，52(n=30)名大腿前皮下脂肪组织匹配，60(n=30)名腹部匹配；因此，每个地标的SAT厚度没有年龄组差异。与年轻人相比，老年人在大腿前部(女性：40.3+/-6.8对52.4+/-7.6；男性：35.7+/-8.0对54.3+/-9.8，p<；0.01)和腹部(女性：38.7+/-27.6对73.4+/-31.0；男性：18.7+/-15.2对60.9+/-23.4，p<；.01)肌肉，而不是上臂前肌(女性：47.0+/-6.5对53.2+/-13.1；男性：43.4+/-8.9对48.9+/-10.1，p=.18)。结论躯干和下肢肌肉的组成与上肢肌肉相比有明显的年龄相关性差异；强调了在评估与年龄相关的肌肉特征时量化特定肌肉组的重要性。
Background Age-related deterioration of muscle mass does not occur uniformly across the body. However, there is limited knowledge on the uniformity of age-related muscle composition changes across the body.Objective Our primary objective was to evaluate muscle composition differences between younger and older adults across multiple muscle groups.Methods We re-analysed data from a previously published cohort to evaluate differences in ultrasound muscle composition (echo intensity) between younger (60 years) adults, when matched for adipose tissue mass at the anterior upper arm, anterior upper leg and abdominal muscles. Analysis of echo intensity is confounded by subcutaneous adipose tissue (SAT) thickness overlaying the muscle; we accounted for these effects by matching older and younger adults (1:1), stratified by sex, for absolute SAT thickness at each landmark.Results From 96 adults (n = females), 58 (n = 34) were SAT matched at the anterior upper arm, 52 (n = 30) at the anterior upper leg and 60 (n = 30) at the abdominal region; thus, there were no age group differences in SAT thickness at each landmark. In comparison with younger adults, older adults presented with greater echo intensity at the anterior upper leg (females:40.3 +/- 6.8 vs. 52.4 +/- 7.6; males:35.7 +/- 8.0 vs. 54.3 +/- 9.8, p < .01) and abdominal (females:38.7 +/- 27.6 vs. 73.4 +/- 31.0; males:18.7 +/- 15.2 vs. 60.9 +/- 23.4, p < .01) muscles, but not anterior upper arm muscles (females:47.0 +/- 6.5 vs. 53.2 +/- 13.1; males:43.4 +/- 8.9 vs. 48.9 +/- 10.1, p = .18).Conclusions Distinct age-related differences in trunk and lower limb muscle composition were evident compared to upper limb muscles; highlighting the importance of quantifying specific muscle groups when evaluating age-associated muscle characteristics.