Therapeutic Opportunities in the Intrinsic Subtypes of Muscle-Invasive Bladder Cancer
Therapeutic Opportunities in the Intrinsic Subtypes of Muscle-Invasive Bladder Cancer
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DOI：
10.1016/j.hoc.2014.11.003
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发表时间：
2015-04-01
影响因子：
2.4
通讯作者：
Dinney, Colin P. N.
中科院分区：
文献类型：
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作者：
McConkey, David J.;Choi, Woonyoung;Dinney, Colin P. N.
最近的研究表明，肌肉浸润性膀胱癌分为内在基底亚型和管腔亚型，与乳腺癌的描述相似。每个亚型都富含潜在的临床可行的基因组改变和表观遗传特征；肿瘤亚型与对传统顺铂化疗的敏感性之间存在关联。作者回顾了内在亚型的生物学和临床特征，并描述了它们对常规和靶向药物开发的影响。肿瘤可塑性似乎在基底和管腔膀胱癌生物学中发挥的作用及其对治疗耐药性发展的潜在影响也进行了讨论。
Recent studies revealed that muscle-invasive bladder cancers segregate into intrinsic basal and luminal subtypes that are similar to those described for breast cancer. Each subtype is enriched with potentially clinically actionable genomic alterations and epigenetic signatures; there are associations between tumor subtype and sensitivity to conventional cisplatin-based chemotherapy. The authors review biological and clinical characteristics of the intrinsic subtypes and describe their implications for the development of conventional and targeted agents. The role that tumor plasticity seems to play in basal and luminal bladder cancer biology and its potential effects on the development of therapeutic resistance is also discussed.