Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore.
Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore.
复制标题
无机多磷酸盐 (polyP) 作为线粒体通透性转换孔的激活剂和结构成分。
DOI：
10.1042/bst20150206
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发表时间：
2016
影响因子：
3.9
通讯作者：
Pavlov,EvgenyV
中科院分区：
文献类型：
--
作者：
Solesio,MariaE;Elustondo,PiaA;Zakharian,Eleonora;Pavlov,EvgenyV
线粒体通透性转换孔（mitochondrialpermeability transition pore，mPTP）是位于线粒体内膜的一个大通道。在病理性钙超载过程中mPTP的开放导致膜去极化和ATP产生的中断。mPTP活化已被认为是应激诱导的细胞死亡过程中的中心事件。mPTP是由多种蛋白质组成的超分子复合物。最近的研究表明，线粒体ATP酶在mPTP的形成中起着中心作用。然而，mPTP的中心传导孔部分（mPTPore）的结构仍然难以捉摸。在这里，我们审查目前提出的mPTPore和参与polyP在其形成和调节模型。我们讨论了被低估的作用polyP作为一个效应器和一个假定的结构组成部分的mPTPore。我们提出的假设，包括聚P可以解释这样的性质的mPTP活动的钙激活，选择性和电压依赖性。
Mitochondrial permeability transition pore (mPTP) is a large channel located in the mitochondrial inner membrane. The opening of mPTP during pathological calcium overload leads to the membrane depolarization and disruption of ATP production. mPTP activation has been implicated as a central event during the process of stress-induced cell death. mPTP is a supramolecular complex composed of many proteins. Recent studies suggest that mitochondrial ATPase plays the central role in the formation of mPTP. However, the structure of the central conducting pore part of mPTP (mPTPore) remains elusive. Here we review current models proposed for the mPTPore and involvement of polyP in its formation and regulation. We discuss the underestimated role of polyP as an effector and a putative structural component of the mPTPore. We propose the hypothesis that inclusion of polyP can explain such properties of mPTP activity as calcium activation, selectivity and voltage-dependence.