Changes in Serum Adiponectin Levels from Birth to Term-Equivalent Age Are Associated with Postnatal Weight Gain in Preterm Infants
Changes in Serum Adiponectin Levels from Birth to Term-Equivalent Age Are Associated with Postnatal Weight Gain in Preterm Infants
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DOI：
10.1159/000322654
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发表时间：
2011-01-01
期刊：
影响因子：
2.5
通讯作者：
Kamoda, Tomohiro
中科院分区：
文献类型：
--
作者：
Saito, Makoto;Nishimura, Kazunori;Kamoda, Tomohiro
背景：脂联素是一种脂肪细胞因子，被认为在胎儿生长发育中起关键作用，可能通过胰岛素增敏作用增强胰岛素的促生长作用。目的和方法：为了研究不同的宫内和出生后发育模式与脂联素分泌的关系，我们测定了30名适龄(AGA)和19名小于胎龄(SGA)早产儿在出生第一天和足月等龄时的血清脂联素水平。结果：所有早产儿从出生到足月儿的血清脂联素水平均显著升高。经胎龄或足月体重调整后，AGA组足月龄脂联素水平显著高于SGA组[平均值(SD)40.4(12.3)mU/ml；P<；0.01]。AGA组从出生到足月同龄的脂联素水平升高显著高于SGA组，并且与联合组的体重增加率(g/kg/d)呈正相关(r=0.37，p<；0.01)。以出生至足月年龄的脂联素增加为因变量对所有受试者进行多元回归分析表明，只有体重增加率与脂联素增加独立相关。结论：我们的结果提示，血清脂联素水平的变化可能反映了早产儿从出生到足月同龄的出生后发育。版权所有(C)2011 S.Karger AG，巴塞尔
Background: Adiponectin, one of the adipocytokines, is postulated to play a key role in fetal growth, probably enhancing the growth-promoting effect of insulin through insulin-sensitizing action. Objectives and Methods: To examine how different intrauterine or postnatal growth patterns relate to adiponectin secretion, we measured serum adiponectin concentrations in 30 appropriate-for-gestational-age (AGA) and 19 small-for-gestational-age (SGA) preterm infants on the first day of life and at term-equivalent age. Results: The serum levels of adiponectin increased significantly in all preterm infants from birth to term-equivalent age. The adiponectin levels at term-equivalent age were significantly higher in the AGA than in the SGA group [mean (SD) 40.4 (12.3) vs. 28.4 (10.4) mu g/ml; p < 0.01] after adjustment for gestational age or term-equivalent body weight. The increase in adiponectin levels from birth to term-equivalent age was significantly higher in the AGA than in the SGA group, and was positively correlated with the weight gain rate (g/kg/day) in the combined groups (r = 0.37, p < 0.01). A multiple regression analysis with the adiponectin increase from birth to term-equivalent age as the dependent variable for all the subjects revealed that only weight gain rate was independently associated with the adiponectin increase. Conclusions: Our results suggest that the change in serum adiponectin levels may reflect postnatal growth from birth to term-equivalent age in preterm infants. Copyright (C) 2011 S. Karger AG, Basel