Macrophage Autophagy and Bacterial Infections.
Macrophage Autophagy and Bacterial Infections.
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DOI：
10.3389/fimmu.2017.01483
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发表时间：
2017
影响因子：
7.3
通讯作者：
Vergne I
中科院分区：
文献类型：
--
作者：
Bah A;Vergne I
自噬是一种高度保守的溶酶体降解途径，在细菌感染中起关键作用。研究最多的一种可能是嗜异性，即溶酶体对细胞内细菌的选择性捕获和降解。然而，自噬的影响超出了异食，并涉及与其他宿主防御机制的密集交叉对话。此外，自噬机制可以具有非经典功能，例如LC 3相关的吞噬作用。在这篇综述中，我们打算总结目前的知识在细胞防御中的自噬蛋白的许多功能，重点是细菌-巨噬细胞的相互作用。我们还介绍了病原体开发的策略，以逃避或利用这一机制，以建立一个成功的感染。最后，我们讨论了自噬操纵在改善细菌病原体的治疗和疫苗方面的机遇和挑战。
Autophagy is a well-conserved lysosomal degradation pathway that plays key roles in bacterial infections. One of the most studied is probably xenophagy, the selective capture and degradation of intracellular bacteria by lysosomes. However, the impact of autophagy goes beyond xenophagy and involves intensive cross-talks with other host defense mechanisms. In addition, autophagy machinery can have non-canonical functions such as LC3-associated phagocytosis. In this review, we intend to summarize the current knowledge on the many functions of autophagy proteins in cell defenses with a focus on bacteria–macrophage interaction. We also present the strategies developed by pathogens to evade or to exploit this machinery in order to establish a successful infection. Finally, we discuss the opportunities and challenges of autophagy manipulation in improving therapeutics and vaccines against bacterial pathogens.