Temporal Lobe Epilepsy: Anatomical and Effective Connectivity
Temporal Lobe Epilepsy: Anatomical and Effective Connectivity
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DOI：
10.1109/tnsre.2008.2006220
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发表时间：
2009-06-01
影响因子：
4.9
通讯作者：
Carney, Paul R.
中科院分区：
文献类型：
--
作者：
Cadotte, Alex J.;Mareci, Thomas H.;Carney, Paul R.
虽然在过去的一个世纪里，颞叶癫痫 (TLE) 可以用抗癫痫药物治疗，但仍有很大一部分患者的癫痫发作仍然无法通过药物治疗。为了更好地理解和治疗 TLE，我们的实验室使用多种体内分析技术来估计癫痫的连通性。本文回顾了两种不同的基于连接的方法，重点是在癫痫研究中的应用。首先，我们提出有效的连接技术，例如格兰杰因果关系，已用于评估大脑区域之间的动态方向关系。这些措施用于更好地了解癫痫发作活动如何启动、传播和终止。其次，结构技术，例如磁共振成像，可用于评估导致癫痫发作的潜在神经结构的变化。本文还包括以体内癫痫为中心的有效和解剖连接分析的示例。这些分析是根据从 TLE 自发癫痫动物模型体内收集的数据进行的。未来的癫痫体内研究无疑将受益于这些不同技术的融合。最后，我们讨论了统一分析可能带来的有趣的可能性、影响和挑战。
While temporal lobe epilepsy (TLE) has been treatable with anti-seizure medications over the past century, there still remain a large percentage of patients whose seizures remain untreatable pharmacologically. To better understand and treat TLE, our laboratory uses several in vivo analytical techniques to estimate connectivity in epilepsy. This paper reviews two different connectivity-based approaches with an emphasis on application to the study of epilepsy. First, we present effective connectivity techniques, such as Granger causality, that has been used to assess the dynamic directional relationships among brain regions. These measures are used to better understand how seizure activity initiates, propagates, and terminates. Second, structural techniques, such as magnetic resonance imaging, can be used to assess changes in the underlying neural structures that result in seizure. This paper also includes in vivo epilepsy-centered examples of both effective and anatomical connectivity analysis. These analyses are performed on data collected in vivo from a spontaneously seizing animal model of TLE. Future work in vivo on epilepsy will no doubt benefit from a fusion of these different techniques. We conclude by discussing the interesting possibilities, implications, and challenges that a unified analysis would present.