Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers.
Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers.
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DOI：
10.1038/nrneurol.2013.36
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发表时间：
2013-04
影响因子：
38.1
通讯作者：
Gandy, Sam
中科院分区：
文献类型：
--
作者：
DeKosky, Steven T.;Blennow, Kaj;Ikonomovic, Milos D.;Gandy, Sam
在过去的十年中，公众对创伤性脑损伤（TBI）的长期病理后果的认识有所提高。有报道称，在拳击和美式足球等高强度运动中遭受反复脑震荡的运动员出现了渐进式神经功能障碍，也有报道称，由于治疗方法的改进，战争退伍军人患脑外伤的人数不断增加，他们现在更有可能在爆炸中幸存下来。此外，慢性创伤性脑病（CTE）——其特征是显著的神经精神特征，包括痴呆、帕金森症、抑郁、躁动、精神病和攻击性——已经越来越多地被认为是重复性TBI的潜在晚期结果。在发达国家，每年约有1%的人口经历临床相关的脑外伤。本综述的目的是概述对CTE病理生理学的最新认识，并描述临床和研究界面临的关键问题，如CTE风险的准确量化，以及单事件TBI和CTE的可靠生物标志物的开发。
Over the past decade, public awareness of the long-term pathological consequences of traumatic brain injury (TBI) has increased. Such awareness has been stimulated mainly by reports of progressive neurological dysfunction in athletes exposed to repetitive concussions in high-impact sports such as boxing and American football, and by the rising number of TBIs in war veterans who are now more likely to survive explosive blasts owing to improved treatment. Moreover, the entity of chronic traumatic encephalopathy (CTE)—which is marked by prominent neuropsychiatric features including dementia, parkinsonism, depression, agitation, psychosis, and aggression—has become increasingly recognized as a potential late outcome of repetitive TBI. Annually, about 1% of the population in developed countries experiences a clinically relevant TBI. The goal of this Review is to provide an overview of the latest understanding of CTE pathophysiology, and to delineate the key issues that are challenging clinical and research communities, such as accurate quantification of the risk of CTE, and development of reliable biomarkers for single-incident TBI and CTE.
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DOI：
10.1192/bjp.105.440.714
发表时间：
1959-01-01
期刊：
JOURNAL OF MENTAL SCIENCE
影响因子：
--
作者：
CORSELLIS, JAN;BRIERLEY, JB
通讯作者：
BRIERLEY, JB
影响因子：
2.4
作者：
Bazarian, Jeffrey J.;Donnelly, Kerry;Zhong, Jianhui
通讯作者：
Zhong, Jianhui
影响因子：
4.8
作者：
Anderson, RE;Hansson, LO;Settergren, G
通讯作者：
Settergren, G
影响因子：
9.9
作者：
Franz, G;Beer, R;Deisenhammer, F
通讯作者：
Deisenhammer, F
影响因子：
--
作者：
CORSELLIS, JAN
通讯作者：
CORSELLIS, JAN