Understanding the relationship between brain gene expression and social behavior: lessons from the honey bee.
Understanding the relationship between brain gene expression and social behavior: lessons from the honey bee.
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DOI：
10.1146/annurev-genet-110711-155517
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发表时间：
2012-11
影响因子：
11.1
通讯作者：
A. Zayed;G. Robinson
中科院分区：
文献类型：
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作者：
A. Zayed;G. Robinson
行为是一种复杂的表型，具有可塑性和进化不稳定性。基因组学的出现通过提供量化与行为输出相关的大脑基因表达的动态性质的工具，彻底改变了行为遗传学领域。蜜蜂是研究大脑基因表达和行为之间关系的一个很好的平台，因为蜜蜂复杂的社会成员表达了显著的行为库，而且行为受遗传和社会环境的影响程度很大。在这里，我们回顾了一系列相关的研究，这些研究分析了蜜蜂大脑转录组的变化与自然和实验诱导的行为状态变化相关。这些实验表明，大脑基因表达与行为密切相关，大脑基因表达的变化介导行为的变化，特定基因与行为之间的关联存在于从生理到进化的多个时间尺度上。
Behavior is a complex phenotype that is plastic and evolutionarily labile. The advent of genomics has revolutionized the field of behavioral genetics by providing tools to quantify the dynamic nature of brain gene expression in relation to behavioral output. The honey bee Apis mellifera provides an excellent platform for investigating the relationship between brain gene expression and behavior given both the remarkable behavioral repertoire expressed by members of its intricate society and the degree to which behavior is influenced by heredity and the social environment. Here, we review a linked series of studies that assayed changes in honey bee brain transcriptomes associated with natural and experimentally induced changes in behavioral state. These experiments demonstrate that brain gene expression is closely linked with behavior, that changes in brain gene expression mediate changes in behavior, and that the association between specific genes and behavior exists over multiple timescales, from physiological to evolutionary.