Role of microbiota in postnatal maturation of intestinal T-cell responses
Role of microbiota in postnatal maturation of intestinal T-cell responses
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DOI：
10.1097/mog.0b013e32834bb82b
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发表时间：
2011-10-01
影响因子：
2.5
通讯作者：
Cerf-Bensussan, Nadine
中科院分区：
文献类型：
--
作者：
Gaboriau-Routhiau, Valerie;Lecuyer, Emelyne;Cerf-Bensussan, Nadine
综述目的原核生物利用其快速生长和持续遗传适应能力，在地球上所有可能的生态环境中定居，包括真核生物的体表和胃肠道。哺乳动物肠道包含10（14）个细菌的复杂群落，其元基因组包含比人类基因组多1500倍的基因。控制真核宿主和肠道细菌共生体之间的关系的力量，因此，成为一个主要的焦点interests.Recent findingsRecent数据强调了哺乳动物宿主和他们的微生物群之间的对话如何刺激出生后成熟的一个有效的肠道屏障，促进生态位殖民共生细菌和反对殖民病原体。在此，我们回顾了微生物群诱导的T细胞反应，并讨论了单个细菌如何塑造调节和炎症反应之间的平衡。我们还将展示宿主因素如何影响肠道免疫反应的结果和影响的microbiota.SummaryDeciphering主机微生物群的相互影响的结构可能不仅有助于理解最近爆发的肠道炎症性疾病，但也指出能够维持或恢复肠道稳态的策略。
Purpose of reviewTaking advantage of their rapid growth and capacity for continuous genetic adaptation, prokaryotes have colonized all possible ecological environments on earth, including the body surfaces of eukaryotes and their gastrointestinal tract. The mammalian gut contains a complex community of 10(14) bacteria with a meta-genome containing 1500-fold more genes than the human genome. The forces that control the relationships between eukaryotic hosts and their intestinal bacterial symbionts have, thus, become a major focus of interest.Recent findingsRecent data have highlighted how the dialogue between mammalian hosts and their microbiota stimulates the postnatal maturation of an efficient intestinal barrier that promotes niche colonization by symbiotic bacteria and opposes colonization by pathogens. Herein, we review microbiota-induced T-cell responses and discuss how individual bacteria may shape the balance between regulatory and inflammatory responses. We will also show how host factors might influence the outcome of gut immune responses and affect the structure of the microbiota.SummaryDeciphering host-microbiota reciprocal influence may not only help in understanding the recent outburst of intestinal inflammatory diseases but also point to strategies able to maintain or restore intestinal homeostasis.