Basis for phase relations between baroreceptor and sympathetic nervous discharge.
Basis for phase relations between baroreceptor and sympathetic nervous discharge.
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压力感受器和交感神经放电之间的相位关系的基础。
DOI：
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发表时间：
1976
影响因子：
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通讯作者：
G. L. Gebber
中科院分区：
文献类型：
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作者：
G. L. Gebber
本文用平均反应计算机研究了麻醉猫的心动周期与交感神经放电（SND）的相位关系。最大SND出现在心率为3~4次/秒的麻醉早期。SND和心动周期之间的相位关系的急剧变化伴随着由刺激切断的右迷走神经的远端产生的心率降低。随着心率逐渐降低至2次/秒，最大SND点从早期舒张期移至收缩期峰值附近，然后进入前一心动周期的舒张晚期。这些观察结果表明，同步SND在每个心动周期是不是简单的结果的压力感受器神经活动的盈亏。相反，1：1锁定突发的SND的心动周期的基础上，解释夹带的压力感受器反射的交感神经节律的中央起源。提出了一种新的相位假设来解释夹带。此外，当SND爆发和心动周期之间的1：1关系在心率低于2次/秒时被破坏时，与颈动脉窦神经的脉冲同步放电相关的交感抑制的两个组成部分（脊髓和脑干）被揭示。
The phase relations between the cardiac cycle and sympathetic nervous discharge (SND) were studied with an average-response computer in the anesthetized cat. Maximum SND occurred during early diastole at heart rates between 3 and 4 beats/s. Dramatic shifts in the phase relations between SND and the cardiac cycle accompanied the decrease in heart rate produced by stimulation of the distal end of the cut right vagus nerve. The point of maximum SND was shifted from early diastole to near peak systole and then into the late diastolic phase of the preceding cardiac cycle as heart rate was progressively lowered to 2 beats/s. These observations indicate that synchronization of SND during each cardiac cycle is not the simple consequence of the waxing and waning of baroreceptor nerve activity. Rather, 1:1 locking of bursts of SND to the cardiac cycle is explained on the basis of entrainment by the baroreceptor reflexes of a sympathetic rhythm of central origin. An inhibitory-phasing hypothesis is proposed to account for entrainment. In addition, two components (spinal and brainstem) of sympathoinhibition associated with the pulse-synchronous discharge of the carotid sinus nerve were revealed when the 1:1 relationship between bursts of SND and the cardiac cycle was disrupted at heart rates below 2 beats/s.