NEW MUTATION CAUSING HEREDITARY HEPATITIS IN THE LABORATORY RAT
NEW MUTATION CAUSING HEREDITARY HEPATITIS IN THE LABORATORY RAT
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DOI：
10.1093/oxfordjournals.jhered.a110416
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发表时间：
1987-11-01
影响因子：
3.1
通讯作者：
MORI, M
中科院分区：
文献类型：
--
作者：
YOSHIDA, MC;MASUDA, R;MORI, M
在LEC品系大鼠中发现了一种新的突变体，可引起与严重黄疸相关的遗传性肝炎。成年大鼠在出生后三到四个月突然出现肝炎。肝炎的临床症状以严重黄疸、皮下出血、少尿和体重减轻为特征。受影响的大鼠表现出高致死率和肝脏组织学变化，伴有扩大的肝细胞局灶性坏死，无炎性细胞反应。基因检测表明，至少有一个常染色体隐性基因是肝炎的主要原因。此外，在黄疸恢复后长期存活的大鼠以及少数无黄疸的无症状大鼠中出现肝癌。因此，LEC大鼠为肝炎和肝癌的基础和临床研究，包括其发病机制，预防和治疗提供了有用的动物模型。
A new mutant causing hereditary hepatitis associated with severe jaundice has been discovered in the LEC strain of rats. Hepatitis appears suddenly in adult rats three to four months after birth. The clinical signs of hepatitis are characterized by severe jaundice, subcutaneous bleeding, oliguria, and loss of body weight. The affected rats showed a high lethality and histological changes of the liver with focal necrosis of enlarged hepatocytes without inflammatory cell response. Genetic tests indicate that at least a single autosomal recessive gene is responsible for the major cause of hepatitis. Furthermore, liver cancer appears in long survived rats after recovery from jaundice as well as a few asymptomatic rats without jaundice. The LEC rats thus provide an animal model useful for the basic and clinical studies of hepatitis and liver cancer, including their pathogenesis, prevention, and treatment.