Virtual time-to-contact identifies balance deficits better than traditional metrics in people with multiple sclerosis
Virtual time-to-contact identifies balance deficits better than traditional metrics in people with multiple sclerosis
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DOI：
10.1007/s00221-019-05698-6
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发表时间：
2019-12-02
影响因子：
2
通讯作者：
Fling, Brett W.
中科院分区：
文献类型：
--
作者：
Whittier, Tyler T.;Richmond, Sutton B.;Fling, Brett W.
多发性硬化症（MS）是一种神经退行性疾病，对整个中枢神经系统的电信号质量产生负面影响。虽然姿势控制受损是多发性硬化症（PwMS）患者最常见的症状之一，但通常报道的指标如压力中心（CoP）路径长度和速度并不能很好地预测跌倒风险。一种相对较新的度量，称为虚拟接触时间（VTC），是一种使用CoP的瞬时位置、速度和加速度来预测CoP到达试验中每个数据点的支持基边界所需时间的测量方法。虽然职业训练局的指标在PwMS方面显示出令人鼓舞的结果，但职业训练局的报告方式仍然不一致。因此，这项工作的目的是比较VTC和通常报道的姿势平衡控制措施，以确定评估PwMS特有的平衡障碍的最合适的指标。一组多发性硬化症患者和一组神经系统健康的对照组在双眼睁开和双眼闭上的情况下进行静态平衡任务。VTC最小值（最小值）在检测条件之间和研究组之间的平衡表现差异方面是最好的。此外，通过Romberg比率评估，VTC最小值在检测PwMS本体感觉弱点方面是最好的。这些结果表明，VTC最小值可能比传统指标更好地检测PwMS特有的平衡障碍以及该人群中的本体感觉缺陷。
Multiple sclerosis (MS) is a neurodegenerative disease that negatively affects the quality of electrical signaling throughout the central nervous system. Although impaired postural control is one of the most common symptoms in people with MS (PwMS), commonly reported metrics such as center of pressure (CoP) path length and velocity have not been great predictors of fall risk. A relatively new metric, known as virtual time-to-contact (VTC), is a measurement that uses the instantaneous position, velocity and acceleration of the CoP, to predict how long it would take the CoP to reach the boundary of the base of support for every data point in a trial. While the VTC metric has shown promising results in PwMS, there are still inconsistencies in how VTC is reported. Thus, the purpose of this work was to compare VTC to commonly reported measures of postural balance control to identify the most appropriate metric(s) for assessing balance impairments unique to PwMS. A group of patients with MS and a group of neurologically healthy controls performed a static balance task with both eyes open and eyes closed. The VTC minimum values (minima) were the best at detecting balance performance differences between conditions and between study groups. In addition, VTC minima was the best at detecting proprioceptive weaknesses in PwMS, assessed via the Romberg ratio. These results suggest that the VTC minima may be better than traditional metrics at detecting balance impairments unique to PwMS as well as proprioceptive deficits within this population.