Analysis of skilled forelimb movement in rats: the single pellet reaching test and staircase test.
Analysis of skilled forelimb movement in rats: the single pellet reaching test and staircase test.
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DOI：
10.1002/0471142301.ns0828s58
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Dunnett, Stephen B
中科院分区：
文献类型：
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作者：
Klein, Alexander;Dunnett, Stephen B
脑损伤、中风和神经退行性疾病（如帕金森氏病或亨廷顿氏病）可导致人类和大鼠熟练使用前肢的严重运动缺陷。这些缺陷通常是在一个达到吃的范式分析。大鼠的熟练伸手被发现是人类熟练伸手的一个很好的模型。因此，大鼠是监测神经损伤后缺陷发展或医疗干预后变化的极好工具。以下方案包括大鼠熟练触及的两种不同测试。单颗粒触地测试是一种范式，涉及对触地动作本身的定性方面进行详细的评级和分析。楼梯测试是一种客观的、高通量的到达任务，允许同时在多只大鼠中研究到达成功率（吃掉的颗粒数量）。这两种测试已被广泛用于研究运动缺陷和治疗效果。
Brain damage, stroke, and neurodegenerative diseases such as Parkinson's or Huntington's disease can cause severe motor deficits in skilled forelimb use in both humans and rats. These deficits are typically analyzed in a reach-to-eat paradigm. Skilled reaching in rats has been found to be a good model of human skilled reaching. Therefore, rats serve as an excellent tool to monitor the development of deficits after neurological insults or changes after medical intervention. The following protocols comprise two different tests of rat skilled reaching. The single pellet reaching test is a paradigm that involves detailed rating and analysis of qualitative aspects of the reaching movement itself. The staircase test is an objective, high-throughput reaching task that allows reaching success (number of pellets eaten) to be investigated in multiple rats at the same time. Both tests have been used extensively to investigate motor deficits and effects of treatment.