The hippocampal formation participates in novel picture encoding: Evidence from functional magnetic resonance imaging
The hippocampal formation participates in novel picture encoding: Evidence from functional magnetic resonance imaging
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DOI：
10.1073/pnas.93.16.8660
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发表时间：
1996-08-06
影响因子：
11.1
通讯作者：
Rosen, BR
中科院分区：
文献类型：
--
作者：
Stern, CE;Corkin, S;Rosen, BR
大量证据支持海马和相关的内侧颞叶结构对长时记忆中信息的编码和储存至关重要的假设。然而，很少有人类成像研究成功地显示了编码或检索过程中这些区域的信号强度变化。使用功能磁共振成像（fMRI），我们研究了正常人受试者，而他们执行一个新的图片编码任务。高速回波平面成像技术评估整个大脑的功能磁共振成像信号的变化。在编码的新图片，统计学上显着增加的fMRI信号观察双边在海马后结构和海马旁回和舌和梭状回。据我们所知，这个实验是第一个功能磁共振成像研究，显示在人类海马区的强大的信号变化。它还提供了证据，新的编码，复杂的图片依赖于腹侧皮质区之间的相互作用，专门为对象的视觉，海马结构和海马旁回，专门为长期记忆。
Considerable evidence exists to support the hypothesis that the hippocampus and related medial temporal lobe structures are crucial for the encoding and storage of information in long-term memory. Few human imaging studies, however have successfully shown signal intensity changes in these areas during encoding or retrieval. Using functional magnetic resonance imaging (fMRI), we studied normal human subjects while they performed a novel picture encoding task. High-speed echo-planar imaging techniques evaluated fMRI signal changes throughout the brain. During the encoding of novel pictures, statistically significant increases in fMRI signal were observed bilaterally in the posterior hippocampal formation and parahippocampal gyrus and in the lingual and fusiform gyri. To our knowledge, this experiment is the first fMRI study to show robust signal changes in the human hippocampal region. It also provides evidence that the encoding of noveI, complex pictures depends upon an interaction between ventral cortical regions, specialized for object vision, and the hippocampal formation and parahippocampal gyrus, specialized for long-term memory.