ALTERATIONS IN NOTCH SIGNALING IN NEOPLASTIC LESIONS OF THE HUMAN CERVIX
ALTERATIONS IN NOTCH SIGNALING IN NEOPLASTIC LESIONS OF THE HUMAN CERVIX
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DOI：
10.1073/pnas.92.14.6414
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发表时间：
1995-07-03
影响因子：
11.1
通讯作者：
ARTAVANISTSAKONAS, S
中科院分区：
文献类型：
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作者：
ZAGOURAS, P;STIFANI, S;ARTAVANISTSAKONAS, S
癌症的发展是一个细胞过程，反映并部分由细胞决定的改变驱动。负责细胞决定的各种分子的突变已被确定为致癌的，但很少有人知道在致癌过程中的正常细胞命运决定机制的参与。Notch途径定义了一种进化上保守的一般细胞相互作用机制，其控制脊椎动物和无脊椎动物发育期间细胞决定的基本方面。我们已经探索了人Notch途径在人宫颈组织中的参与，其定义了细胞命运发生变化的细胞环境，并且肿瘤条件已经得到很好的表征。我们的证据表明，Notch表达与正在经历细胞命运变化的细胞群相关，并且Notch活性可用于监测宫颈以及其他上皮瘤变中的细胞命运异常。
The development of cancer is a cellular process that reflects and is partly driven by alterations in cell determination. Mutations in various molecules responsible for cell determination have been identified as being oncogenic, but little is known about the involvement of normal cell fate-determining mechanisms in the oncogenic process. The Notch pathway defines an evolutionarily conserved, general cell interaction mechanism that controls fundamental aspects of cell determination during vertebrate and invertebrate development. We have explored the involvement of the human Notch pathway in human cervical tissues, which define a cellular environment where cell fate changes take place and where neoplastic conditions have been well characterized. Our evidence suggests that Notch expression is associated with cell populations that are undergoing cell fate changes and that Notch activity can be used to monitor cell fate abnormalities in cervical as well as other epithelial neoplasias.