Associations Between Thinner Retinal Neuronal Layers and Suboptimal Brain Structural Integrity in a Middle-Aged Cohort.
Associations Between Thinner Retinal Neuronal Layers and Suboptimal Brain Structural Integrity in a Middle-Aged Cohort.
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DOI：
10.2147/eb.s402510
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发表时间：
2023
期刊：
影响因子：
4.4
通讯作者：
Poulton, Richie
中科院分区：
文献类型：
--
作者：
Barrett-Young, Ashleigh;Abraham, Wickliffe C.;Cheung, Carol Y.;Gale, Jesse;Hogan, Sean;Ireland, David;Keenan, Ross;Knodt, Annchen R.;Melzer, Tracy R.;Moffitt, Terrie E.;Ramrakha, Sandhya;Tham, Yih Chung;Wilson, Graham A.;Wong, Tien Yin;Hariri, Ahmad R.;Poulton, Richie
视网膜具有作为脑健康和阿尔茨海默病（AD）的生物标志物的潜力，因为它是中枢神经系统中唯一可以容易地成像的部分，并且具有优于脑成像技术的优势。很少有研究比较了中年样本的视网膜和大脑测量结果。我们的研究目的是调查是否视网膜神经元测量与结构脑测量在中年人群为基础的队列。参与者是达尼丁多学科健康与发展研究的成员（n=1037;纵向队列从出生到3岁，5岁，7岁，9岁，11岁，13岁，15岁，18岁，21岁，26岁，32岁，38岁，以及最近的45岁，94%的活着的研究成员参与）。光学相干断层扫描（OCT）测量视网膜神经纤维层（RNFL）和神经节细胞-内丛状层（GC-IPL）厚度。通过磁共振成像（MRI）测量脑年龄差距估计值（brainAGE）、皮质表面积、皮质厚度、皮质下灰质体积、白色高信号。具有MRI和OCT数据的参与者被纳入分析（RNFL n=828，女性n=413 [49.9%]，男性n=415 [50.1%]; GC-IPL n=825，女性n=413 [50.1%]，男性n=412 [49.9%]）。较薄的视网膜神经元层与脑年龄较大、皮质表面积较小、平均皮质较薄、皮质下灰质体积较小和白色物质高信号体积增加相关。这些发现提供了证据表明，视网膜神经元层反映了中年大脑结构完整性的差异，与后期AD风险增加一致，支持视网膜可能是大脑健康的早期生物标志物的主张。
The retina has potential as a biomarker of brain health and Alzheimer’s disease (AD) because it is the only part of the central nervous system which can be easily imaged and has advantages over brain imaging technologies. Few studies have compared retinal and brain measurements in a middle-aged sample. The objective of our study was to investigate whether retinal neuronal measurements were associated with structural brain measurements in a middle-aged population-based cohort. Participants were members of the Dunedin Multidisciplinary Health and Development Study (n=1037; a longitudinal cohort followed from birth and at ages 3, 5, 7, 9, 11, 13, 15, 18, 21, 26, 32, 38, and most recently at age 45, when 94% of the living Study members participated). Retinal nerve fibre layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness were measured by optical coherence tomography (OCT). Brain age gap estimate (brainAGE), cortical surface area, cortical thickness, subcortical grey matter volumes, white matter hyperintensities, were measured by magnetic resonance imaging (MRI). Participants with both MRI and OCT data were included in the analysis (RNFL n=828, female n=413 [49.9%], male n=415 [50.1%]; GC-IPL n=825, female n=413 [50.1%], male n=412 [49.9%]). Thinner retinal neuronal layers were associated with older brain age, smaller cortical surface area, thinner average cortex, smaller subcortical grey matter volumes, and increased volume of white matter hyperintensities. These findings provide evidence that the retinal neuronal layers reflect differences in midlife structural brain integrity consistent with increased risk for later AD, supporting the proposition that the retina may be an early biomarker of brain health.