INVIVO STUDIES OF UNLABELED AND RADIOIODINATED RHODAMINE-123
INVIVO STUDIES OF UNLABELED AND RADIOIODINATED RHODAMINE-123
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DOI：
10.1016/0883-2897(92)90126-j
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发表时间：
1992-04-01
影响因子：
3.1
通讯作者：
DHALLA, M
中科院分区：
文献类型：
--
作者：
VORA, MM;DHALLA, M
将潜在的肿瘤显像剂--放射性碘化罗丹明123(Rh123)注射到实验性诱发肿瘤的小鼠体内，观察其组织分布。在肿瘤中发现了一些放射性积聚，其中大部分在注射后迅速从血液中清除。此外，放射性碘标记的Rh123已代谢成可溶于水的物质，并在尿液和粪便中排泄，而未标记的Rh123则仅在肿瘤中少量蓄积。然而，它被发现在心脏中大量积聚；在注射后4小时，它的积聚水平是血液水平的70倍。即使在注射后24小时，未标记的Rh123的积聚也在稳步增加，但通过肾脏从血液中迅速清除。这一发现可以用于合成C-11和F-18标记的Rh123，用于心肌的PET研究。
Radioiodinated rhodamine-123 (Rh123), potential tumor imaging agent, was injected in mice bearing experimentally-induced tumors to investigate its tissue distribution. Some accumulation of radioactivity was found in tumors; most of it cleared rapidly from the blood after injection. Also, the radioiodinated Rh123 had metabolized to water-soluble species which was excreted in urine and feces.Unlabeled Rh123, on the other hand, accumulated only marginally in the tumors. However, it was found to accumulate significantly in the heart; as much as seventy times the level in blood at 4h post-injection. Accumulation of unlabeled Rh123 increased steadily even at 24 h post-injection; whereas, it cleared rapidly from the blood via the kidney.This finding of selective accumulation of Rh123 in heart could be exploited in synthesizing C-11 and F-18-labeled Rh123 for use in PET studies of the myocardium.