The role of neurotensin in passive avoidance learning in the rat central nucleus of amygdala
The role of neurotensin in passive avoidance learning in the rat central nucleus of amygdala
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DOI：
10.1016/j.bbr.2011.08.041
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发表时间：
2012-01-15
影响因子：
2.7
通讯作者：
Lenard, Laszlo
中科院分区：
文献类型：
--
作者：
Laszlo, Kristof;Toth, Krisztian;Lenard, Laszlo
神经降压素（NT）是一种神经递质和/或神经调质，在学习和强化过程中发挥作用。杏仁中央核（CeA）富含NT和神经降压素1受体（NTS 1），参与记忆和学习机制的调节。本研究旨在观察NT和NTS 1拮抗剂（ANT）注射于雄性Wistar大鼠脑前区后对被动回避学习的影响。NT显著延长潜伏期。NT的作用可被ANT预处理所阻断。蚂蚁本身没有影响。我们的结果表明，在大鼠中，CeA NT通过NTS 1促进被动回避学习。(C)2011年由Elsevier出版。
Tridecapeptide neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reinforcement. The central nucleus of amygdala (CeA), which is relatively rich in NT and neurotensin-1 receptors (NTS1), participates in the regulation of memory and learning mechanisms. The aim of this study was to examine the possible effect of NT and NTS1 antagonist (ANT) on passive avoidance learning after their microinjection into the CeA of male wistar rats. NT significantly increased the latency time. Effect of NT was blocked by ANT pretreatment. ANT in itself had no effect. Our results show that in the rat CeA NT facilitates passive avoidance learning via NTS1. (C) 2011 Published by Elsevier By.