Gating of information flow within the limbic system and the pathophysiology of schizophrenia
Gating of information flow within the limbic system and the pathophysiology of schizophrenia
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DOI：
10.1016/s0165-0173(99)00049-1
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发表时间：
2000-03-01
影响因子：
--
通讯作者：
Grace, AA
中科院分区：
文献类型：
--
作者：
Grace, AA
尽管最初被认为是一种多巴胺能障碍，但几乎没有直接证据支持多巴胺系统的主要病理学是精神分裂症的病因。相比之下，越来越多的证据支持这种疾病存在皮质紊乱。其后果之一是皮质下多巴胺系统的皮质调节受到破坏。我们的研究表明，海马体在这种相互作用中发挥着重要作用，因为它与多巴胺系统一起，对来自伏隔核水平的前额皮质的信息行提供门控影响。此外，化学诱导的海马和内嗅皮层发育破坏会导致成年大鼠边缘系统中这些相互作用的病理生理变化。因此，精神分裂症被认为是一种与发育相关的疾病，其中在个体发育过程中海马对边缘系统的影响的破坏导致成年有机体中皮质层相互作用的病理改变。 (C) 2000 Elsevier Science B.V. 保留所有权利。
Although first thought of as a dopaminergic disorder, there is little direct evidence to support a primary pathology in the dopamine system as the etiological factor in schizophrenia. In contrast, evidence is amassing in support of a cortical disturbance in this disorder; one consequence of which is a disruption in the cortical regulation of subcortical dopamine systems. Our studies show that the hippocampus plays a major role in this interaction, in that, along with the dopamine system, it provides a gating influence over information Row from the prefrontal cortex at the level of the nucleus accumbens. Moreover, chemically-induced disruption of the development of the hippocampus and entorhinal cortex were found to lead to pathophysiological changes in these interactions in the limbic system of adult rats. Therefore, schizophrenia is proposed to be a developmentally-related disorder, in which disruption of the hippocampal influence over the limbic system during ontogeny results in a pathological alteration of corticoaccumbens interactions in the adult organism. (C) 2000 Elsevier Science B.V. All rights reserved.