The human Y chromosome derives largely from a single autosomal region added to the sex chromosomes 80-130 million years ago
The human Y chromosome derives largely from a single autosomal region added to the sex chromosomes 80-130 million years ago
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DOI：
10.1159/000056872
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发表时间：
2001-01-01
期刊：
影响因子：
--
通讯作者：
Graves, JAM
中科院分区：
文献类型：
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作者：
Waters, PD;Duffy, B;Graves, JAM
人类X染色体基因在远亲哺乳动物中的定位已经确定了一个在所有三个现存哺乳动物群体中X染色体共有的保守区域，加上一个最近被添加到真兽目X染色体中但在有袋类和单孔目动物中仍然是常染色体的区域。利用人类Y基因的比较作图，我们现在直接表明，真兽Y也是由一个保守的和一个添加的区域，其中包含大多数无处不在的表达Y基因。几乎没有古老的保守区域保留下来，人类Y染色体主要来自增加的区域。版权所有（C）2001 S. Karger AG，巴塞尔。
Mapping of human X-borne genes in distantly related mammals has defined a conserved region shared by the X chromosome in all three extant mammalian groups, plus a region that was recently added to the eutherian X but is still autosomal in marsupials and monotremes. Using comparative mapping of human Y-borne genes, we now directly show that the eutherian Y is also composed of a conserved and an added region which contains most of the ubiquitously expressed Y-borne genes. Little of the ancient conserved region remains, and the human Y chromosome is largely derived from the added region. Copyright (C) 2001 S. Karger AG, Basel.