Seven years of recording from monkey cortex with a chronically implanted multiple microelectrode.
Seven years of recording from monkey cortex with a chronically implanted multiple microelectrode.
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DOI：
10.3389/fneng.2010.00006
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Rizzolatti G
中科院分区：
文献类型：
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作者：
Krüger J;Caruana F;Volta RD;Rizzolatti G
将64根微丝的刷子长期植入猕猴的腹侧运动前皮质。与通常的方法相反，电线从白色物质一侧插入。这种方法，通过避免机械压力的硬脑膜和软脑膜在穿透，干扰只有最低限度的皮质记录网站。通过这种方法，在大约三分之一的电极中记录了7年多的隔离电位和多单位活动。间接插入方法还在每个记录会话中提供了极好的稳定性，并且在某些情况下甚至允许从相同的神经元记录数年。对植入大脑区域的组织学检查显示，记录区域仅受到非常轻微的损伤。讨论了长期记录的优点和问题。
A brush of 64 microwires was chronically implanted in the ventral premotor cortex of a macaque monkey. Contrary to common approaches, the wires were inserted from the white matter side. This approach, by avoiding mechanical pressure on the dura and pia mater during penetration, disturbed only minimally the cortical recording site. With this approach isolated potentials and multiunit activity were recorded for more than 7 years in about one-third of electrodes. The indirect insertion method also provided an excellent stability within each recording session, and in some cases even allowed recording from the same neurons for several years. Histological examination of the implanted brain region shows only a very marginal damage to the recording area. Advantages and problems related to long-term recording are discussed.