Safety and acceptability of pneumococcal vaccinations administered in nontraditional settings
Safety and acceptability of pneumococcal vaccinations administered in nontraditional settings
复制标题
DOI：
10.1067/mic.2002.121554
复制
发表时间：
2002-08-01
影响因子：
4.9
通讯作者：
Nichol, KL
中科院分区：
文献类型：
--
作者：
D'Heilly, S;Bauman, WL;Nichol, KL
背景资料：关注的安全性和可接受性的疫苗管理在非传统的设置可能会离开病人和他们的供应商不愿意利用非传统的设置为immunizations.Methods：老年人接受肺炎球菌疫苗接种在这些设置进行了调查，结构化问卷。他们被问及疫苗接种后一周与比较时间段内的局部和全身症状。结果：在方便样本中包括的1136人中，有636人做出了回答（56%）。接种后一周与对照周相比，全身症状的发生率通常相似或较低，尽管接种后一周发热更常见（3% vs 0.3%; P <0.01）。接种疫苗后，23.1%的人出现任何局部症状（疼痛、发红或肿胀）。既往接种过疫苗的受试者比首次接种疫苗的受试者或不确定其疫苗接种状态的受试者更有可能报告局部发红或肿胀（分别为13.1% vs 4.4% vs 1.4%; P = 0.001）。在多变量分析中，局部症状与接种后发热密切相关（校正比值比，13.15; P < .001），再接种与局部症状密切相关（校正比值比，3.77：P < .001）。100%的受访者非常或有点满意他们的经验，和>99%会推荐一个非传统的设置给朋友或家人member.Conclusion：非传统的设置提供了一个安全和非常满意的选择，为管理肺炎球菌疫苗接种的老年人。
Background: Concerns about the safety and acceptability of vaccine administration in nontraditional settings might leave patients and their providers reluctant to take advantage of nontraditional settings for immunizations.Methods: Elderly persons who received pneumococcal vaccinations in these settings were surveyed with a structured questionnaire. They were asked about local and systemic symptoms during the postvaccination week versus a comparison time period.Results: Of the 1136 people included in the convenience sample, 636 responded (56%). Systemic symptoms were generally at similar or lower rates for the postvaccination week versus the comparison week, although fever was more common during the postvaccination week (3% vs 0.3%; P < .01). After vaccination 23.1% had any local symptom (soreness, redness, or swelling). Subjects who had been previously vaccinated were more likely to report local redness or swelling than were first-time vaccine recipients or people who were unsure of their vaccination status (13.1% vs 4.4% vs 1.4%, respectively; P = .001). In multivariate analyses, local symptoms were strongly associated with fever after vaccination (adjusted odds ratio, 13.15; P < .001), and revaccination was strongly associated with local symptoms (adjusted odds ratio, 3.77: P < .001). One hundred percent of respondents were very or somewhat satisfied with their experience, and >99% would recommend a nontraditional setting to a friend or family member.Conclusion: Nontraditional settings offer a safe and highly satisfactory option for the administration of pneumococcal vaccinations to the elderly.