Occupational rhinitis induced by capsaicin.
Occupational rhinitis induced by capsaicin.
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DOI：
10.4168/aair.2012.4.2.104
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Park HS
中科院分区：
文献类型：
--
作者：
Nam YH;Jin HJ;Hwang EK;Shin YS;Ye YM;Park HS
辣椒素是红辣椒的香料成分。它很容易被吸入，引起可重复的咳嗽并引起人鼻粘膜的分泌反应。迄今为止，尚无辣椒素引起职业性鼻炎（OR）的报道。我们报道了一名 44 岁女工厂工人的病例，她在接触辣椒素 4 年后患上了职业性鼻炎。她出现了鼻塞、流鼻涕和鼻子发痒的症状，这些症状在工作场所接触后更加严重。通过皮肤点刺试验，患者对所有常见的吸入性过敏原（包括辣椒素）均呈阴性反应。辣椒素鼻激发试验显示，激发后10分钟鼻部症状评分和嗜酸性粒细胞计数增加，1～3小时后下降；对屋尘螨过敏原没有明显反应。患者搬迁并开始药物治疗1个月后，工作性鼻炎好转。据我们所知，这是第一例在工作场所接触辣椒素引起的手术室病例。我们提供的证据表明 OR 可能是由非免疫机制介导的。
Capsaicin is the spice component of red pepper. It can be easily inhaled, inducing a reproducible cough and provokes a secretory response from the human nasal mucosa. To date, there has been no report of occupational rhinitis (OR) caused by capsaicin. We report the case of a 44-year-old female mill worker who developed occupational rhinitis after 4 years of exposure to capsaicin. She developed nasal congestion, rhinorrhea, and itchy nose, which were all aggravated upon exposure at the workplace. The patient had negative responses to all common inhalant allergens, including capsaicin, by skin prick tests. The nasal provocation test with capsaicin showed that the nasal symptom score and eosinophil count increased 10 minutes after the provocation and decreased after 1 to 3 hours; no significant response was noted to house dust mite allergen. The patient's work-related rhinitis improved 1 month after she relocated and started pharmacological treatment. To our knowledge, this is the first case of OR caused by capsaicin exposure in the workplace. We provide evidence suggesting that OR may be mediated by a non-immunological mechanism.
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DOI：
10.4168/aair.2010.2.2.77
发表时间：
2010-04
期刊：
Allergy, asthma & immunology research
影响因子：
--
作者：
Thong BY
通讯作者：
Thong BY
影响因子：
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作者：
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通讯作者：
Dicpinigaitis, PV
影响因子：
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作者：
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通讯作者：
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通讯作者：
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影响因子：
5
作者：
Fujimoto, S;Mori, M;Kunimatsu, M
通讯作者：
Kunimatsu, M