Plasma and CSF markers of oxidative stress are increased in Parkinson's disease and influenced by antiparkinsonian medication
Plasma and CSF markers of oxidative stress are increased in Parkinson's disease and influenced by antiparkinsonian medication
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DOI：
10.1016/j.nbd.2003.10.003
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发表时间：
2004-02-01
影响因子：
6.1
通讯作者：
Beisiegel, U
中科院分区：
文献类型：
--
作者：
Buhmann, C;Arlt, S;Beisiegel, U
我们通过测量体外脂蛋白氧化以及血浆和脑脊液（CSF）中的水和亲脂性抗氧化剂水平，确定了帕金森病（PD）患者、其他神经系统疾病（OND）患者和健康对照组的全身氧化应激。此外，我们研究了左旋多巴（LD）和多巴胺受体激动剂治疗（DA）对PD患者氧化状态的影响。我们发现，与OND患者和对照组相比，PD患者的氧化应激增加，表现为血浆和CSF中脂蛋白氧化水平较高，蛋白巯基（SH）组血浆水平降低，CSF中α-生育酚水平较低。左旋多巴治疗并没有显着改变血浆脂蛋白氧化，但LD单一疗法往往会导致增加的自氧化和减少的血浆抗氧化剂与泛醇-10的意义。DA单药治疗与较高的α-生育酚水平显著相关。接受DA单药治疗或与DA联合用药的患者表现出降低脂蛋白氧化的趋势。这些数据支持氧化应激作为PD发病机制中的一个因素的概念，并可能是一个潜在的促氧化作用的LD和DA在PD治疗中可能的抗氧化作用的指标。(C)2003年爱思唯尔公司All rights reserved.
We determined systemic oxidative stress in Parkinson's disease (PD) patients, patients with other neurological diseases (OND) and healthy controls by measurement of in vitro lipoprotein oxidation and levels of hydro- and lipophilic antioxidants in plasma and cerebrospinal fluid (CSF). Additionally, we investigated the influence of levodopa (LD) and dopamine agonist therapy (DA) on the oxidative status in PD patients. We found increased oxidative stress, seen as higher levels of lipoprotein oxidation in plasma and CSF, decrease of plasma levels of protein sulfhydryl (SH) groups and lower CSF levels of alpha-tocopherol in PD patients compared to OND patients and controls. Levodopa treatment did not significantly change the plasma lipoprotein oxidation but LD monotherapy tended to result in an increase of autooxidation and in a decrease of plasma antioxidants with significance for ubiquinol-10. DA monotherapy was significantly associated with higher alpha-tocopherol levels. Patients with DA monotherapy or co-medication with DA showed a trend to lower lipoprotein oxidation. These data support the concept of oxidative stress as a factor in the pathogenesis of PD and might be an indicator of a potential prooxidative role of LD and a possible antioxidative effect of DA in PD treatment. (C) 2003 Elsevier Inc. All rights reserved.