The Avon Longitudinal Study of Parents and Children (ALSPAC) - study design and collaborative opportunities
The Avon Longitudinal Study of Parents and Children (ALSPAC) - study design and collaborative opportunities
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DOI：
10.1530/eje.0.151u119
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发表时间：
2004-11-01
影响因子：
5.8
通讯作者：
Golding, J
中科院分区：
文献类型：
--
作者：
Golding, J
雅芳父母和儿童纵向研究（ALSPAC）是一项基于人群的研究，旨在了解随着时间的推移，物理和社会环境与基因型相互作用的方式，以影响健康，行为和发育。这些关于常见疾病和病症中因果关系相互作用的信息将为未来的预防干预措施提供基础，特别是针对具有特定基因型的人。虽然ALSPAC建立在早期一般人群队列产生的数据和假设的基础上，但其设计提供了特殊的优势，最重要的是：在怀孕早期登记;从儿童和父母那里储存DNA（允许进行遗传传递测试和跨代印记研究）;多种生理、心理和环境措施;一个地理基地（允许医疗记录和学校联系;家庭环境措施和诊所直接检查）;从7岁起每年对整个队列进行动手检查。登记的14 541名孕妇（预产期为1991年4月1日至1992年12月31日）约占合格人口的85%。13 9 71名儿童谁仍然活着，在12个月的年龄，主要是由父母完成的问卷调查。12年过去了，调查问卷仍在向11300个家庭发出。母亲的平均问卷答复率为79%。从7岁起，每年对儿童进行“身体”和“心理”方面的检查（每个“诊所”约有8 000人参加）。在验证研究中，数据的质量很高，并通过与每个专业领域的专家合作加以维护。高参与率确保了未来可行的研究。
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a population-based study designed to understand the ways in which the physical and social environment interact, over time, with the genotype to affect health, behaviour and development. This information about causal interactions in common diseases and disorders will provide the basis on which future preventive interventions can be tested, especially in regard to people with specific genotypes. Whilst ALSPAC builds on data and hypotheses generated by earlier general population cohorts, its design offers special advantages, the most important being: enrolment in early pregnancy; banking of DNA from the children and parents (permitting genetic transmission tests and transgenerational imprinting studies); diverse physical, psychological and environmental measures; one geographical base (permitting medical record and school linkage; environmental measures in the home, and clinics for direct examination); annual hands-on examinations of the full cohort since age 7. The 14 541 enrolled pregnancies (expected date of delivery 1 April 1991 to 31 December 1992) represented about 85% of the eligible population. The 13 9 71 children who were still alive at age 12 months have been followed principally by questionnaires completed by a parent. Twelve years on, questionnaires are still being sent out to 11300 families. The average questionnaire response rate from mothers is 79%. From age 7, annual examinations of both 'physical' and 'psychological' aspects have also been conducted on the children (approximately 8000 attend each 'clinic'). The quality of the data has proved high in validation studies and is maintained by collaboration with experts in each specialist field. The high participation rate ensures a viable study well into the future.