Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women
Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women
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DOI：
10.1179/147683008x301450
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发表时间：
2008-04-01
影响因子：
3.6
通讯作者：
Snodderly, D. Max
中科院分区：
文献类型：
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作者：
Johnson, Elizabeth J.;McDonald, Karen;Snodderly, D. Max
简介：低的二十二碳六烯酸（DHA）和/或富含叶黄素的食物的饮食摄入量可能与认知能力下降的风险增加在elderized.Subjects和方法：DHA和叶黄素在未受损的老年妇女的认知益处进行了探讨的背景下，4个月，双盲，DHA和叶黄素补充剂的眼睛健康的干预试验。49名女性（年龄60-80岁）被随机分配接受DHA（800 mg/天; n = 14），叶黄素（12 mg/天; n = 11），DHA和叶黄素的组合（n = 14）或安慰剂（n = 10）。受试者接受认知测试，测量语言流畅性，记忆，处理速度和准确性，并在随机化和完成后的trial.Results的情绪自我报告：补充后，语言流畅性评分显着改善DHA，叶黄素，联合治疗组（P < 0.03）。联合治疗组的记忆成绩和学习速度明显改善（P < 0.03），学习效率也有提高的趋势（P = 0.07）。心理处理速度，准确性和情绪的措施没有受到影响的supplementation.Conclusions：这些探索性的研究结果表明，DHA和叶黄素补充剂可能对老年人的认知有益。
Introduction: Low dietary intake of docosahexaenoic acid (DHA) and/or foods rich in lutein may be associated with increased risk of cognitive decline in the elderly.Subjects and methods: The cognitive benefit of DHA and lutein in unimpaired elder women was explored in the context of a 4-month, double-blind, intervention trial of DHA and lutein supplementation for eye health. Forty-nine women (aged 60-80 years) were randomized to receive DHA (800 mg/day; n = 14), lutein (12 mg/day; n = 11) a combination of DHA and lutein (n = 14) or placebo (n = 10). Subjects underwent cognitive tests measuring verbal fluency, memory, processing speed and accuracy, and self-reports of mood at randomization and upon completion of the trial.Results: Following supplementation, verbal fluency scores improved significantly in the DHA, lutein, and combined treatment groups (P < 0.03). Memory scores and rate of learning improved significantly in the combined treatment group (P < 0.03), who also displayed a trend toward more efficient learning (P = 0.07). Measures of mental processing speed, accuracy and mood were not affected by supplementation.Conclusions: These exploratory findings suggest that DHA and lutein supplementation may have cognitive benefit for older adults.