Redox of ferrocene controlled asymmetric dehydrogenative Heck reaction via palladium-catalyzed dual C-H bond activation
Redox of ferrocene controlled asymmetric dehydrogenative Heck reaction via palladium-catalyzed dual C-H bond activation
复制标题
通过钯催化双 C-H 键活化控制二茂铁的氧化还原不对称脱氢 Heck 反应
DOI：
10.1039/c3sc50577d
复制
发表时间：
2013-01-01
期刊：
影响因子：
8.4
通讯作者：
Wu, Yangjie
中科院分区：
文献类型：
--
作者：
Pi, Chao;Li, Ying;Wu, Yangjie
开发了一种由二茂铁氧化还原过程控制的脱氢 Heck 反应的新策略。以市售手性氨基酸为配体，实现了不对称脱氢 Heck 反应，得到了具有优异对映选择性和良好收率（高达 99% ee 和 98% 收率）的平面手性二茂铁衍生物。
A novel strategy of dehydrogenative Heck reaction controlled by redox process of ferrocene has been developed. Commercially available chiral amino acid as ligand realized asymmetric dehydrogenative Heck reaction, leading to planar-chiral ferrocene derivatives with excellent enantioselectivity and in good to excellent yields (up to 99% ee and 98% yield).