Decreased Vascular and Increased Adrenal and Renal Sensitivity to Angiotensin II in the Newborn Lamb
Decreased Vascular and Increased Adrenal and Renal Sensitivity to Angiotensin II in the Newborn Lamb
复制标题
新生羔羊血管减少，肾上腺和肾脏对血管紧张素 II 的敏感性增加
DOI：
10.1161/01.res.48.1.34
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发表时间：
1981
影响因子：
20.1
通讯作者：
S. Siegel
中科院分区：
文献类型：
--
作者：
S. Siegel
采用2 ~ 3周龄羔羊，研究了2组血管紧张素II （0.025 /ig/kg / min和0.25 /μ/kg / min）对血浆肾素活性（PRA）、醛固酮浓度、肌酐清除率和钠钾排泄量的影响。研究了0.025 μ/kg / min剂量的血管紧张素II对6只成年母羊的影响。血管紧张素II输注后，新生儿PRA在30分钟分别从基线的24.5±2.3 ng/ml / hr （mean±SE）和22.9±3.5下降到13.6±0.8和13.0±2.2 (P < 0.01)，并在60分钟恢复到基线水平；母羊的PRA在30分钟时从1.7±0.1降至0.95±0.3 ng/ml / hr (P < 0.01)， 60分钟时恢复到基线水平。新生儿血浆醛固酮在15分钟时分别从基线值17.4±5.0 ng/ dl和14.7±3.9增加到33.1±6.9和32.5±6.3 (P < 0.01)，并在60分钟时恢复到基线值。母羊血浆醛固酮从4.3±0.7增加到9.2±2.0 ng/dl，并在60分钟时恢复到基线水平。低、高血管紧张素剂量下新生羔羊的PRA和醛固酮反应从基线到峰值的变化相似，且大于母羊（P < 0.01）。肌酐清除率、血浆钠或红细胞压积没有变化。0.25 /μ/kg / min血管紧张素组新生儿尿钠总量由0.16±0.04 mEq/ 30min增加至0.87±0.27 （P < 0.05）。我们得出结论，在基础条件下，与成年羔羊相比，新生羔羊具有较高的PRA和醛固酮水平，血压降低，醛固酮和肾素释放对血管紧张素H的反应性增加。Circ Res 48: 34-38, 1981
The effects of two doses of angiotensin II (0.025 /ig/kg per min and 0.25 /μ/kg per min) on plasma renin activity (PRA), aldosterone concentration, creatinine clearance, and sodium and potassium excretion were studied in two groups of 2- to 3-week-old lambs. The 0.025 μ/kg per min dose of angiotensin II also was studied in six adult ewes. In response to the angiotensin II infusions, PRA decreased in the newborns from baselines of 24.5 ± 2.3 ng/ml per hr (mean ± SE) and 22.9 ± 3.5 to 13.6 ± 0.8 and 13.0 ± 2.2 at 30 minutes (P < 0.01), respectively, and returned to baseline at 60 minutes; PRA decreased from 1.7 ± 0.1 to 0.95 ± 0.3 ng/ml per hr at 30 minutes (P < 0.01) in the ewe and returned to baseline at 60 minutes. Plasma aldosterone increased in the newborns from baselines of 17.4 ± 5.0 ng/ dl and 14.7 ± 3.9 to 33.1 ± 6.9 and 32.5 ± 6.3, respectively, at 15 minutes (P < 0.01) and returned to baseline at 60 minutes. Plasma aldosterone increased from 4.3 ± 0.7 to 9.2 ± 2.0 ng/dl in the ewe, and returned to baseline at 60 minutes. The change in the PRA and aldosterone responses from baseline to peak for the low and high angiotensin dose was similar in the newborn lambs and greater than in the ewe (P < 0.01). There was no change in the creatinine clearance, plasma sodium, or hematocrit. Urine sodium excretion increased from 0.16 ± 0.04 total mEq/30 min to 0.87 ± 0.27 (P < 0.05) in the newborns during the 0.25 /μ/kg per min angiotensin II infusion. We conclude that, under basal conditions, the newborn lamb has high PRA and aldosterone levels with decreased pressor and increased aldosterone and renin release responsiveness to angiotensin H compared to the adult. Circ Res 48: 34-38, 1981