Prefrontal cortex-mediated executive function as assessed by Stroop task performance associates with weight loss among overweight and obese adolescents and young adults
Prefrontal cortex-mediated executive function as assessed by Stroop task performance associates with weight loss among overweight and obese adolescents and young adults
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DOI：
10.1016/j.bbr.2016.12.040
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发表时间：
2017-03
影响因子：
2.7
通讯作者：
Xia Xu;Zhangyan Deng;Qin Huang;Wei-Xia Zhang;Changzhu Qi;Jiaai Huang
中科院分区：
文献类型：
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作者：
Xia Xu;Zhangyan Deng;Qin Huang;Wei-Xia Zhang;Changzhu Qi;Jiaai Huang
有认知缺陷或执行功能障碍的人通常超重或肥胖。一些人类神经影像学研究发现，执行功能（EF）预测食物摄入和体重增加;然而，很少有研究调查EF和体重减轻之间的关系。Stroop任务是EF的经典测量方法，用于许多神经影像学研究。在目前的工作中，功能性近红外光谱（fNIRS）数据收集期间的Stroop任务的样本超重或肥胖的青少年和年轻人（n = 31）谁参加了夏季健身和减肥营。我们通过干扰视觉挑战的反应时间（RT）和通过fNIRS检测的氧合血红蛋白水平的改变来评估Stroop效应。与以前的研究一致，我们发现Stroop效应在肥胖/超重个体中被不同的视觉任务条件成功地诱导。此外，我们的研究结果表明，更好的Stroop任务的表现与更大的体重减轻超过4周的健身干预。事实上，行为数据表明，减少RT干扰预示着更大比例的体重减轻。此外，由于Stroop效应，左腹外侧和双侧背外侧前额叶皮层的血流动力学反应更大的超重/肥胖个体在短期健身干预期间比这些神经区域激活水平较低的参与者减轻了更多的体重。总的来说，我们的研究结果支持前额叶皮层介导的EF在影响食物摄入和减肥结果中的作用，在以前未研究的年龄段的人口。
People with cognitive deficits or executive dysfunction are often overweight or obese. Several human neuroimaging studies have found that executive function (EF) predicts food intake and weight gain; however, fewer studies have investigated the relationship between EF and weight loss. The Stroop task is a classic measure of EF that is used in many neuroimaging studies. In the present work, functional near infrared spectroscopy (fNIRS) data were collected during performance of the Stroop task from a sample of overweight or obese adolescents and young adults (n = 31) who participated in a summer fitness and weight loss camp. We assessed the Stroop effect by interference in the reaction time (RT) to visual challenges, and by alterations in levels of oxygenated hemoglobin, as detected by fNIRS. In line with previous studies, we found that the Stroop effect was successfully induced by different visual task conditions among obese/overweight individuals. Moreover, our results reveal that better Stroop task performance is correlated with greater weight loss over a4-weekfitness intervention. Indeed, behavioral data demonstrated that reduced RT interference predicted a greater percentage of weight loss. Moreover, overweight/obese individuals with a greater hemodynamic response in the left ventrolateral and bilateral dorsolateral prefrontal cortex due to the Stroop effect lost more weight during the short-term fitness intervention than participants with lower levels of activation of these neural regions. Overall, our results support a role for prefrontal cortex-mediated EF in influencing food intake and weight loss outcomes in a population of a previously unstudied age.