RAGE Gene Polymorphisms Are Associated with Circulating Levels of Endogenous Secretory RAGE but Not with Coronary Artery Disease in Chinese Patients with Type 2 Diabetes Mellitus
RAGE Gene Polymorphisms Are Associated with Circulating Levels of Endogenous Secretory RAGE but Not with Coronary Artery Disease in Chinese Patients with Type 2 Diabetes Mellitus
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DOI：
10.1016/j.arcmed.2009.06.008
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发表时间：
2009-07-01
影响因子：
7.7
通讯作者：
Shen, Wei Feng
中科院分区：
文献类型：
--
作者：
Peng, Wen Hui;Lu, Lin;Shen, Wei Feng
背景和目标。晚期糖基化终产物受体（RAGE）与晚期糖基化终产物的结合以及随后的信号传导在糖尿病并发症的发生中发挥着重要作用。这种病理生理效应部分减轻内源性分泌激素（esophagus）。本研究旨在探讨中国人2型糖尿病患者血清雌二醇水平与冠心病的关系。共入组了740例接受冠状动脉造影术的T2 DM连续患者。冠状动脉粥样硬化的严重程度定义为病变血管的数量; 69 bp插入/缺失通过聚合酶链反应确定，-429 T/C，-374 A/T和G82 S变异通过聚合酶链反应-限制性片段长度多态性进行评估。携带-429 T/C的C等位基因和G82 S的G等位基因的患者血清雌二醇水平显著高于携带-429 T/C的C等位基因和G82 S的G等位基因的患者。82 S等位基因也与肿瘤坏死因子-α升高相关。糖尿病合并冠心病患者血清白细胞介素-6水平的变化（均为p
Background and Aims. Engagement of the receptor for advanced glycation end products (RAGE) with advanced glycation end products and subsequent signaling play an important role in the development of diabetic complications. This pathophysiological effect was mitigated partially by endogenous secretory RAGE (esRAGE). The present study aimed to C explore the possible association of RAGE polymorphism with serum esRAGE level and coronary artery disease (CAD) in Chinese patients with type 2 diabetes mellitus T2DM).Methods. A total of 740 consecutive patients with T2DM undergoing coronary angiography were enrolled. The severity of coronary atherosclerosis was defined as the number of diseased vessels; 69 bp insertion/deletion was determined by polymerase chain reactions, and -429 T/C, -374A/T and G82S variants were assessed by polymerase chain reaction-restriction fragment length polymorphism.Results. Patients with genotypes carrying C allele of -429 T/C and G allele of G82S had significantly higher esRAGE levels. 82S allele was also associated with increased tumor necrosis factor-a. and interleukin-6 levels in diabetic patients with CAD (all p