Morphology in preclinical of the cerebral cortex Huntington's disease
Morphology in preclinical of the cerebral cortex Huntington's disease
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DOI：
10.1176/appi.ajp.2007.06081266
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发表时间：
2007-09-01
影响因子：
17.7
通讯作者：
Paulsen, Jane S.
中科院分区：
文献类型：
--
作者：
Nopoulos, Peg;Magnotta, Vincent A.;Paulsen, Jane S.
目的：对已知的亨廷顿病基因扩增和无明显疾病的受试者的皮质形态进行评估。方法：对24例临床前亨廷顿病患者进行磁共振成像扫描，并与24例匹配的健康受试者进行比较，采用新的成像方法对皮质结构进行量化。结果：与对照组相比，临床前亨廷顿病患者表现为皮质形态改变，脑回顶增大，脑沟异常稀薄。结论：这些发现支持神经发育异常可能是亨廷顿病发病过程中的一个重要过程。
Objective: Cortical morphology was evaluated in subjects with known gene expansion for Huntington's disease and no manifest disease.Method: Magnetic resonance imaging scans were obtained for 24 subjects with preclinical Huntington's disease and were compared to those for 24 matched healthy subjects by means of novel imaging methods to quantify aspects of cortical structure.Results: In relation to the comparison subjects, those with preclinical Huntington's disease showed altered cortex morphology with enlargement of gyral crowns and abnormally thin sulci. These changes were manifested in global alterations of gyral and sulcal shape.Conclusion: These findings lend support to the notion that, in addition to the degenerative process, abnormal neural development may also be an important process in the pathoetiology of Huntington's disease.