The Evolving Nature of Biocatalysis in Pharmaceutical Research and Development.
The Evolving Nature of Biocatalysis in Pharmaceutical Research and Development.
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DOI：
10.1021/jacsau.2c00712
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发表时间：
2023-03-27
期刊：
影响因子：
8
通讯作者：
Martinez, Carlos A
中科院分区：
文献类型：
--
作者：
France, Scott P;Lewis, Russell D;Martinez, Carlos A
生物催化是一种非常有价值的药物研究和开发技术，因为它可以以无与伦比的选择性和效率解锁复杂手性基序的合成路线。这一观点旨在回顾生物催化在早期和后期发展的制药实施方面的最新进展，重点是制备规模合成过程的实施。
Biocatalysis is a highly valued enabling technology for pharmaceutical research and development as it can unlock synthetic routes to complex chiral motifs with unparalleled selectivity and efficiency. This perspective aims to review recent advances in the pharmaceutical implementation of biocatalysis across early and late-stage development with a focus on the implementation of processes for preparative-scale syntheses.