The role of the microenvironment and intercellular cross-talk in tumor angiogenesis
The role of the microenvironment and intercellular cross-talk in tumor angiogenesis
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DOI：
10.1006/scbi.2001.0418
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发表时间：
2002-04-01
影响因子：
14.5
通讯作者：
Ellis, LM
中科院分区：
文献类型：
--
作者：
Ahmad, SA;Jung, YD;Ellis, LM
血管生成因子的表达。肿瘤是由肿瘤内的内在因素和宿主微环境控制的。特定肿瘤微环境中的内皮细胞不仅与肿瘤细胞相互作用，而且与免疫细胞、成纤维细胞、周细胞和细胞外基质（ECM）相互作用。这些细胞之间的关系和相互作用决定了基因表达、表型差异，并最终决定了内皮细胞是否存活、增殖或凋亡。血管生成因子在不同部位肿瘤中表达的多样性，以及不同器官和肿瘤中内皮细胞表型不同的事实，构成了开发有效抗血管生成疗法的巨大挑战。
The expression of angiogenic factors in. tumors is controlled by intrinsic factors in the tumor and by the host microenvironment. Endothelial cells within particular tumor microenvironments interact not only with tumor cells but also with immune cells, fibroblasts, pericytes, and the extracellular matrix (ECM). The relationship and cross-talk among these cells determine gene expression, phenotypic distinction, and ultimately whether endothelial cells survive, proliferate, or undergo apoptosis. The diversity of angiogenic factor expression in tumors at different sites, combined with the fact that endothelial cells in different organs and tumors are phenotypically distinct, constitutes a formidable challenge for the development of effective anti-angiogenic therapies.