Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments?
Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments?
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发表时间：
1994-09
影响因子：
9.8
通讯作者：
D. Carmelli;L. Cardon;R. Fabsitz
中科院分区：
文献类型：
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作者：
D. Carmelli;L. Cardon;R. Fabsitz
我们研究了遗传因素在高血压、糖尿病和肥胖症聚集中的中介作用，使用了由国家科学院-国家研究理事会维护的孪生注册。研究样本包括2,508对出生于1917年至1927年之间的男性双胞胎，他们回答了一份邮寄的问卷，调查内容包括人口统计变量、心血管风险因素和健康行为。该队列中高血压和糖尿病的发生率是通过受试者对医生诊断的自我报告和/或处方药的使用来确定的。根据自我报告的身高和体重计算出的身体质量指数被用作肥胖的衡量标准。描述性分析显示，MZ双生子中高血压与糖尿病、高血压与肥胖、糖尿病与肥胖联合发生的概率符合率分别为34.0%、31.2%和32.7%。DZ双生子的符合率分别为8.1%、14.9%和2.8%。在同一个体中，所有三种疾病聚集的概率符合率在MZ对为31.6%，在DZ对为6.3%(相对危险度5.0；X2(1)=2.6；P<；0.15)。对发生这些情况的风险相关性的多变量遗传模拟表明，在这对双胞胎样本中，存在一个共同的潜在因素，调节高血压、糖尿病和肥胖症的聚集。这一共同因素既受遗传因素的影响，又受环境因素的影响(遗传因素占59%，环境因素占41%)。对共同潜在因子的遗传影响是由于显性来源而不是加性来源；环境影响似乎是特定的，而不是同卵双胞胎共享的。
We investigated the mediating role of genetic factors in the clustering of hypertension, diabetes, and obesity, using the twin registry maintained by the National Academy of Sciences--National Research Council. The study sample included 2,508 male twin pairs born between 1917 and 1927 who responded to a mailed questionnaire that covered demographic variables, cardiovascular risk factors, and health behaviors. The incidence of hypertension and diabetes in this cohort was ascertained from subjects' self-report of a physician diagnosis and/or the use of prescription medications. The body-mass index calculated from self-reports of height and weight was used as a measure of obesity. Descriptive analyses indicated probandwise concordance rates of 34.0%, 31.2%, and 32.7%, respectively, for the joint occurrences of hypertension and diabetes, hypertension and obesity, and diabetes and obesity in MZ twin pairs. Corresponding concordance rates in DZ twin pairs were 8.1%, 14.9%, and 2.8%. The probandwise concordance for the clustering of all three conditions in the same individuals was 31.6% in MZ pairs and 6.3% in DZ pairs (relative risk 5.0; X2(1) = 2.6; P < .15). Multivariate genetic modeling of the correlation in liabilities to develop these conditions suggested the presence of a common latent factor mediating the clustering of hypertension, diabetes, and obesity in this twin sample. This common factor was influenced by both genetic and environmental effects (59% 8 genetic, 41% environmental). The genetic influences on the common latent factor were due to dominant rather than additive sources; the environmental influences appeared to be specific rather than shared by co-twins.