THE THIP-INDUCED MODEL OF BILATERAL SYNCHRONOUS SPIKE AND WAVE IN RODENTS
THE THIP-INDUCED MODEL OF BILATERAL SYNCHRONOUS SPIKE AND WAVE IN RODENTS
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DOI：
10.1016/0028-3908(87)90204-8
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发表时间：
1987-02-01
影响因子：
4.7
通讯作者：
GOLDEN, GT
中科院分区：
文献类型：
--
作者：
FARIELLO, RG;GOLDEN, GT
腹腔注射5-10 mg/kg THIP（4，5，6，7-tetrahydroxyisoxazolo（4，5，c）pyridine 3-ol）可诱导大鼠产生短暂、可靠的双侧同步棘波和波模型。由THIP引起的阵发性爆发具有与在幼稚大鼠中经常观察到的自发发生的棘波和波放电相似的地形分布。两种模型皮层下核团对电刺激的反应性不同。THIP的全身给药提供了一种简单、可靠的双侧同步棘波和波放电模型，其可能涉及与自发性发作产生所涉及的相同的脑结构。给药增加了阵发性反应的发生率，并提供了一个稳定和可预测的4小时试验情况，可以很容易地量化。
Intraperitoneal administration of 5-10 mg/kg of THIP (4,5,6,7 tetrahydroxyisoxazolo(4,5,c) pyridine 3-ol) induced a transient, reliable model of bilaterally synchronous spikes and waves in rats. The paroxysmal bursts elicited by THIP had similar topographical distribution to the spontaneously-occurring spike and wave discharges often observed in naive rats. The responsiveness to electrical stimulation of subcortical nuclei was different in the two models. Systemic administration of THIP provided a simple, reliable model of bilaterally synchronous spike and wave discharges that may involve the same cerebral structures as those involved in the generation of the spontaneous paroxysms. The administration of the drug increased the yield of paroxysmal responses and provided a stable and predictable 4 hr test situation that may easily by quantified.