L-arabinose feeding prevents increases due to dietary sucrose in lipogenic enzymes and triacylglycerol levels in rats
L-arabinose feeding prevents increases due to dietary sucrose in lipogenic enzymes and triacylglycerol levels in rats
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DOI：
10.1093/jn/131.3.796
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发表时间：
2001-03-01
影响因子：
4.2
通讯作者：
Iritani, N
中科院分区：
文献类型：
--
作者：
Osaki, S;Kimura, T;Iritani, N
l -阿拉伯糖是一种天然的，不易吸收的戊糖，选择性地抑制肠道蔗糖酶活性。为了研究l -阿拉伯糖对蔗糖酶的抑制作用对脂肪生成的影响，大鼠饲喂0-30 g蔗糖/100 g饲粮，其中0-1 gl -阿拉伯糖/100 g，持续10 d。饲粮中添加蔗糖可显著提高肝脏脂肪生成酶活性和甘油三酯浓度，而阿拉伯糖可显著阻止这种增加。阿拉伯糖饲喂降低了附睾脂肪组织的重量。此外，饲粮中添加l -阿拉伯糖可显著降低血浆胰岛素和甘油三酯浓度。这些发现表明，l -阿拉伯糖抑制肠道蔗糖酶活性，从而减少蔗糖的利用，从而减少脂肪生成。
L-Arabinose is a natural, poorly absorbed pentose that selectively inhibits intestinal sucrase activity. To investigate the effects of L-arabinose feeding on lipogenesis due to its inhibition of sucrase, rats were fed 0-30 g sucrose/100 g diets containing 0-1 g L-arabinose/100 g for 10 d. Lipogenic enzyme activities and triacylglycerol concentrations in the liver were significantly increased by dietary sucrose, and arabinose significantly prevented these increases. Arabinose feeding reduced the weights of epididymal adipose tissue. Moreover, plasma insulin and triacylglycerol concentrations were significantly reduced by dietary L-arabinose. These findings suggest that L-arabinose inhibits intestinal sucrase activity, thereby reducing sucrose utilization, and consequently decreasing lipogenesis.