Catalyst-free three-component sequencing for efficient assembly of [1,3] oxazine N-fused imidazole-2-thiones
Catalyst-free three-component sequencing for efficient assembly of [1,3] oxazine N-fused imidazole-2-thiones
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DOI：
10.1039/c8gc01766b
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发表时间：
2018-08
期刊：
影响因子：
9.8
通讯作者：
En Chen;Jiaan Shao;P. Tang;K. Shu;Wenteng Chen;Yongping Yu
中科院分区：
文献类型：
--
作者：
En Chen;Jiaan Shao;P. Tang;K. Shu;Wenteng Chen;Yongping Yu
由胺醇、乙二醛一水合物和 KSCN 进行的一锅、无催化剂、三组分连续双环化过程经历了亚胺形成/分子内环化/[3 + 2]环加成。这种串联绿色反应在温和的条件下提供了[1,3]恶嗪N-稠合咪唑-2-硫酮，反应时间非常短，官能团变化范围广，在克级规模上具有高效性，并可进行基团辅助纯化化学后处理。
A one-pot, catalyst-free, three-component sequential double-annulation from amine alcohols, glyoxal monohydrates and KSCN underwent imine formation/intramolecular cyclization/[3 + 2] cycloaddition. This tandem and green reaction offered [1,3] oxazine N-fused imidazole-2-thiones in a mild condition, with a very short reaction time, wide variation in functional groups, high efficacy on the gram-large scale and followed group-assisted purification chemistry work-up.