Localization of kappa opioid receptors in oxytocin magnocellular neurons in the paraventricular and supraoptic nuclei.
Localization of kappa opioid receptors in oxytocin magnocellular neurons in the paraventricular and supraoptic nuclei.
复制标题
室旁核和视上核催产素大细胞神经元中卡帕阿片受体的定位。
DOI：
10.1016/s0006-8993(01)02154-0
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发表时间：
2001
期刊：
影响因子：
2.9
通讯作者：
Wise,PM
中科院分区：
文献类型：
--
作者：
Smith,MJ;Wise,PM
先前已经证明κ阿片受体激动剂，如强啡肽，抑制大鼠中的催产素分泌。为了确定κ激动剂是否直接作用于含催产素的大细胞神经元以抑制激素分泌，我们利用免疫荧光法检测大鼠室旁核和视上核中κ阿片受体的细胞定位。κ阿片受体免疫反应与含催产素的细胞体及其轴突和轴突终末共定位。因此，我们的研究结果表明，κ阿片受体激动剂可以对催产素大细胞神经元产生直接的抑制作用。
It has been demonstrated previously that κ opioid receptor agonists, such as dynorphin, inhibit oxytocin secretion in the rat. To determine whether κ agonists act directly on oxytocin-containing magnocellular neurons to inhibit hormone secretion, we utilized immunofluorescence to examine the cellular localization of κ opioid receptors in the rat paraventricular and supraoptic nuclei. κ Opioid receptor immunoreactivity co-localized with oxytocin-containing cell bodies, their axons and axon terminals. Thus, our results suggest that κ opioid receptor agonists can exert direct inhibitory actions on oxytocin magnocellular neurons.