A simple quantitative chiral analysis of amino acid esters by fluorine-19 nuclear magnetic resonance using the modified James-Bull method
A simple quantitative chiral analysis of amino acid esters by fluorine-19 nuclear magnetic resonance using the modified James-Bull method
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DOI：
10.1002/chir.23028
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发表时间：
2019-01-01
期刊：
影响因子：
2
通讯作者：
Ohta, Tetsuo
中科院分区：
文献类型：
--
作者：
Hamaguchi, Naoto;Okuno, Yuta;Ohta, Tetsuo
用改进的James-Bull方法进行了19氟核磁共振(F-19核磁共振)对氨基酸酯的简单手性分析。因此，氨基酸酯盐在三乙胺(TEA)和MS4A存在下与5-氟-2-甲酰基苯基硼酸和(S)-联苯醚反应10分钟。反应混合物直接用F-19核磁共振进行了分析，得到了较好的定量结果。
A simple chiral analysis of amino acid esters by fluorine-19 nuclear magnetic resonance (F-19 NMR) through the modified James-Bull method is described. Thus, amino acid ester acid salt was treated with 5-fluoro-2-formylphenylboronic acid and (S)-BINOL in the presence of triethylamine (TEA) and MS4A for 10 minutes. The reaction mixture was analysed by F-19 NMR directly to afford good quantifications.