Evaluation of indium-111 chloride as a radiopharmaceutical for joint imaging in a rabbit model of arthritis.
Evaluation of indium-111 chloride as a radiopharmaceutical for joint imaging in a rabbit model of arthritis.
复制标题
氯化铟 111 作为放射性药物用于兔关节炎模型关节成像的评价。
DOI：
10.1097/00004424-198709000-00007
复制
发表时间：
1987
影响因子：
6.7
通讯作者：
Sledge,C
中科院分区：
文献类型：
--
作者：
Zalutsky,MR;deSousa,M;Venkatesan,P;Shortkroff,S;Zuckerman,J;Sledge,C
在抗原诱导的关节炎兔模型中研究了111 In-Cl作为放射性药物用于定量滑膜炎程度的潜在用途。对患有单关节疾病的家兔注射111氯化铟，并在30分钟和24、48、72和96小时进行成像。在对照膝关节中，膝关节与大腿软组织区域的活动比率保持恒定（1.5-1.85：1）;在关节炎膝关节中，111 In摄取比率在随后的时间点从2：1增加到3.2、3.5、3.9和4.6：1。对照组和受累关节的膝关节与软组织的比值差异有显著性（P<0.05）。01，48-96小时）。组织分布测量表明，关节炎关节滑膜及其覆盖的关节内结构中111 In浓度最高。在对照组的关节中，这些组织的活动减少了十倍。根据图像计算的111 In膝关节与软组织的比值与滑膜炎严重程度的组织学评估之间存在良好的相关性。
The potential use of 111 In-chloride as a radiopharmaceutical for quantitating the extent of synovitis was investigated in a rabbit model of antigen-induced arthritis. Rabbits with monoarticular disease were injected with 111 In-chloride and imaged at 30 minutes and 24, 48, 72, and 96 hours. In control knee joints, the ratio of activity in the knee to a soft-tissue region in the thigh remained constant (1.5–1.85: 1); in arthritic knees, the 111 In uptake ratio increased from 2: 1 to 3.2, 3.5, 3.9, and 4.6: 1 at the later time points. The difference between the knee-to-soft-tissue ratios observed in the control and involved joints was significant (P<. 01, 48–96 hr). Tissue distribution measurements demonstrated that the synovium and intra-articular structures covered by synovium in arthritic joints had the highest concentration of 111 In. In control joints, these tissues were found to take up tenfold less activity. Good correlation was observed between the 111 In knee-to-soft-tissue ratios calculated from the images and histologic assessment of the severity of synovitis.