Risk of ovarian cancer in relation to prediagnostic levels of C-peptide, insulin-like growth factor binding proteins-1 and -2 (USA, Sweden, Italy).
Risk of ovarian cancer in relation to prediagnostic levels of C-peptide, insulin-like growth factor binding proteins-1 and -2 (USA, Sweden, Italy).
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卵巢癌的风险与 C 肽、胰岛素样生长因子结合蛋白-1 和 -2 的诊断前水平有关（美国、瑞典、意大利）。
DOI：
10.1023/a:1023688603547
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Kaaks,Rudolf
中科院分区：
文献类型：
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作者：
Lukanova,Annekatrin;Lundin,Eva;Micheli,Andrea;Akhmedkhanov,Arslan;Rinaldi,Sabina;Muti,Paola;Lenner,Per;Biessy,Carine;Krogh,Vittorio;Riboli,Elio;Hallmans,Göran;Berrino,Franco;Zeleniuch-Jacquotte,Anne;Toniolo,Paolo;Kaaks,Rudolf
目的：探讨胰腺胰岛素分泌标志物C-肽和胰岛素样生长因子结合蛋白-1和-2作为胰岛素样生长因子-I生物活性指标的诊断前循环水平与卵巢癌发病风险的关系。研究对象为132名献血后至少一年确诊为原发性侵袭性卵巢上皮癌的妇女。对于每个病例，选择两个对照对象，在队列、绝经状态、年龄和征兵日期方面与病例对象匹配(n=263)。结果：校正BMI和空腹后，C肽与四分位数的多肽浓度发生卵巢癌的优势比及其95%可信区间分别为：1.00、0.66(0.35~1.23)、0.96(0.51~1.82)和0.89(0.44~1.81)；IGFBP-1为1.00、1.10(0.58-2.09)、1.07(0.55-2.04)和0.79(0.38-1.62)；IGFBP-2为1.00、1.01(0.54-1.89)、0.98(0.51-1.88)和0.87(0.45-1.68)。在55岁以前诊断为卵巢癌的女性中，IGFBP-1和IGFBP-2的OR值分别为0.51(0.18~1.49)和0.53(0.18~1.54)。结论：本研究不支持C肽在卵巢癌发病中的独立直接病因作用，但提示循环IGFBP-1和IGFBP-2在55岁前发生卵巢癌的妇女中可能具有保护作用。
Objective: To investigate the association of prediagnostic circulating levels of C-peptide, as a marker of pancreatic insulin secretion, and IGF binding proteins -1 and -2, as indicators of the biologically active IGF-I concentration, with risk of developing ovarian cancer.Methods: The study was nested within three prospective cohorts in New York (USA), Umeå (Sweden) and Milan (Italy). Case subjects were 132 women with primary invasive epithelial ovarian cancer diagnosed at least one year after blood donation. For each case, two control subjects were selected, matching the case subject on cohort, menopausal status, age and date of recruitment (n = 263). Only women who did not use exogenous hormones at blood donation were included in the study.Results: Odds ratios and their 95% confidence intervals for risk of developing ovarian cancer over quartiles of peptides concentrations after adjustment for BMI and fasting were: 1.00, 0.66 (0.35–1.23), 0.96 (0.51–1.82) and 0.89 (0.44–1.81) for C-peptide; 1.00, 1.10 (0.58–2.09), 1.07 (0.55–2.04) and 0.79 (0.38–1.62) for IGFBP-1; and 1.00, 1.01 (0.54–1.89), 0.98 (0.51–1.88) and 0.87 (0.45–1.68) for IGFBP-2. In women who had ovarian cancer diagnosis before age 55 the ORs for the top tertiles of IGFBP-1 and IGFBP-2 were 0.51 (0.18–1.49) and 0.53 (0.18–1.54), respectively.Conclusions: This study does not support an independent direct etiological role of C-peptide in ovarian cancer pathogenesis, but suggests a possible protective effect of circulating IGFBP-1 and -2 in women who develop ovarian cancer before age 55.