Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells
Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells
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DOI：
10.1016/s1074-7613(00)80551-8
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发表时间：
1998-04-01
期刊：
影响因子：
32.4
通讯作者：
Nolan, GP
中科院分区：
文献类型：
--
作者：
Hitoshi, Y;Lorens, J;Nolan, GP
Fas是细胞表面的一种受体，可以传递细胞凋亡的信号。使用逆转录病毒cDNA文库为基础的功能克隆，我们确定了一个基因，toso，阻止PAS介导的细胞凋亡。Toso表达仅限于淋巴细胞，并在T细胞中的细胞特异性活化过程后增强。Toso似乎仅限于抑制由TNF受体家族成员介导的细胞凋亡，并且能够抑制由上调Pas配体的TCR活化过程诱导的T细胞自我杀伤。我们将Toso的作用映射为抑制caspase-8加工，这是Fas介导的信号传导中最上游的caspase活性，可能通过激活cFLIP。因此，Toso作为Fas介导的细胞凋亡的一种新的调节剂，并可能作为T细胞和其他造血谱系中细胞命运的调节剂。
Fas is a surface receptor that can transmit signals for apoptosis. Using retroviral cDNA library-based functional cloning we identified a gene, toso, that blocks Pas-mediated apoptosis. Toso expression was confined to lymphoid cells and was enhanced after cell-specific activation processes in T cells. Toso appeared limited to inhibition of apoptosis mediated by members of the TNF receptor family and was capable of inhibiting T cell self-killing induced by TCR activation processes that up-regulate Pas ligand. We mapped the effect of Toso to inhibition of caspase-8 processing, the most upstream caspase activity in Fas-mediated signaling, potentially through activation of cFLIP. Toso therefore serves as a novel regulator of Fas-mediated apoptosis and may act as a regulator of cell fate in T cells and other hematopoietic lineages.