Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women
Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women
复制标题
DOI：
10.2337/db06-1504
复制
发表时间：
2007-03-01
期刊：
影响因子：
7.7
通讯作者：
Rizza, Robert A.
中科院分区：
文献类型：
--
作者：
Basu, Rita;Dalla Man, Chiara;Rizza, Robert A.
为了确定脱氢表雄酮 (DHEA) 替代品是否可以改善胰岛素分泌、胰岛素作用和/或餐后葡萄糖代谢，112 名 DHEA 相对缺乏的老年受试者摄入了标记的混合餐，并在使用 DHEA 或安慰剂 2 年前和之后进行了频繁采样的静脉葡萄糖耐量测试。尽管恢复了在年轻男性和女性中观察到的 DHEA 硫酸盐浓度值，但空腹和餐后葡萄糖浓度、进餐外观、葡萄糖处理和内源性葡萄糖产生随时间的变化与服用安慰剂 2 年后观察到的变化相同。在接受 DHEA 或安慰剂治疗的男性中，餐后和静脉内葡萄糖耐量试验胰岛素和 C 肽浓度随时间的变化没有差异。相比之下，接受 DHEA 治疗的女性的餐后和静脉葡萄糖耐量试验中胰岛素和 C 肽浓度随时间的变化大于安慰剂治疗后的女性 (P < 0.05)。然而，由于 DHEA 倾向于降低胰岛素作用，因此接受 DHEA 治疗和安慰剂治疗的女性的处置指数随时间的变化没有差异，这表明胰岛素分泌的轻微增加是对胰岛素作用轻微降低的补偿反应。我们的结论是，老年男性和女性补充 DHEA 2 年并不能改善胰岛素分泌、胰岛素作用或餐后模式。葡萄糖代谢。
To determine if dehydroepiandrosterone (DHEA) replacement improves insulin secretion, insulin action, and/or postprandial glucose metabolism, 112 elderly subjects with relative DHEA deficiency ingested a labeled mixed meal and underwent a frequently sampled intravenous glucose tolerance test before and after 2 years of either DHEA or placebo. Despite restoring DHEA sulphate concentrations values observed in young men and women, the changes over time in fasting and postprandial glucose concentrations, meal appearance, glucose disposal, and endogenous glucose production were identical to those observed after 2 years of placebo. The change over time in postmeal and intravenous glucose tolerance test insulin and C-peptide concentrations did not differ in men treated with DHEA or placebo. In contrast, postmeal and intravenous glucose tolerance test change over time in insulin and C-peptide concentrations were greater (P < 0.05) in women after DHEA than after placebo. However, since DHEA tended decrease insulin action, the change over time in disposition indexes did not differ between DHEA- and placebo-treate women, indicating that the slight increase in insulin secretion was a compensatory response to a slight decrease in insulin action. We conclude that 2 years of replacement of DHEA in elderly men and women does not improve insulin secretion, insulin action, or the pattern of postprandial. glucose metabolism.