Catalytic enantioselective hydrogenation of vinyl bis(boronates)
Catalytic enantioselective hydrogenation of vinyl bis(boronates)
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DOI：
10.1021/ja044396g
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发表时间：
2004-12-01
影响因子：
15
通讯作者：
Morken, JP
中科院分区：
文献类型：
--
作者：
Morgan, JB;Morken, JP
前手性乙烯基金属试剂的催化对映选择性加氢为烯烃的金属加氢和双金属化提供了一种有吸引力的替代方法。在这个贡献中，描述了乙烯基硼酯的第一个高度对映选择性加氢。手性还原产物是一种用途广泛的化学合成中间体。
Catalytic enantioselective hydrogenation of prochiral vinylmetallic reagents can provide an attractive alternative to hydrometalation and bismetalation of alkenes. In this contribution, the first highly enantioselective hydrogenation of vinyl boronic esters is described. The chiral reduction products are versatile intermediates for chemical synthesis.