From genes to psychoses and back: the role of the 5HT2α-receptor and prepulse inhibition in schizophrenia
From genes to psychoses and back: the role of the 5HT2α-receptor and prepulse inhibition in schizophrenia
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DOI：
10.1007/s00406-008-5011-5
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发表时间：
2008-11-01
影响因子：
4.7
通讯作者：
Hurlemann, Rene
中科院分区：
文献类型：
--
作者：
Maier, Wolfgang;Moessner, Rainald;Hurlemann, Rene
将精神分裂症分解为神经生物学脆弱性特征对于理解这种现象学定义的疾病的复杂遗传基础是必要的。该问题的讨论重点是作为神经生物学表型的前脉冲抑制 (PPI) 和作为候选基因的 5HT2a 受体。最近的一系列研究表明，PPI 和 5HT2a 受体是精神分裂症的脆弱性标记； 5HT2a 基因中的功能序列变异促成了这种关系，并可能因此导致精神分裂症的遗传易感性，但风险增加非常小。
Decomposition of schizophrenia into neurobiological vulnerability traits is necessary to understand the complex genetic underpinnings of this phenomenologically defined disorder. This issue is discussed with a focus on prepulse inhibition (PPI) as a neurobiological phenotype and the 5HT2a-receptor as a candidate gene. A series of recent studies illuminates that PPI and 5HT2a-receptors present as vulnerability markers for schizophrenia; a functional sequence variant in the 5HT2a-gene is contributing to this relationship and might consequently contribute to the genetic predisposition to schizophrenia with a very small risk increase.